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Clinical Profile and Outcome of Pediatric Demyelinating Disorders in Calabar, Nigeria: A Case Series.
Niger J Clin Pract
June 2024
Department of Paediatrics, University of Calabar Teaching Hospital, Calabar, Nigeria.
Background: Demyelinating disorders of the central nervous system (CNS) are rare disorders characterized by inflammation and the selective destruction of CNS myelin. The incidence of this disorder is increasing in developed countries. Nigerian studies on the pediatric population on the subject are very scarce.
View Article and Find Full Text PDFTuberculous Paraplegia: Outcome of Operative Intervention.
Niger J Clin Pract
May 2024
Department of Orthopaedic Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.
Background: Tuberculosis of the spine, a common manifestation of extra-pulmonary tuberculosis is characterized by vertebral destruction, paradiscal involvement, abscess collection and varying degrees of neurologic affectation. The primary disease caused by mycobacterium tuberculosis complex infects the lungs, lymph nodes of the mediastinum and gastrointestinal tract/ viscera with spinal involvement being secondary and caused by haematogenous spread. Tuberculous paraplegia arises as a complication of spinal involvement.
View Article and Find Full Text PDFPott's Paraplegia in a 2 Years Female: A Rare Presentation at an Early Age.
Case Rep Infect Dis
April 2024
Nepal Cardio Diabetes and Thyroid Center, Kathmandu, Nepal.
Introduction: Potts disease is extrapulmonary skeletal tuberculosis mostly affecting the thoracolumbar spine. It destroys the disc space, adjacent vertebral bodies, and spinal elements, leading to cord compression and paraplegia.
Methods: This is a case report study of a 29-month-old toddler who presented to our hospital with bilateral lower limb weakness.
Preoperative embolisation of renal cell carcinoma metastases to the spine - evaluation of procedural and clinical outcome.
Pol J Radiol
March 2024
Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, Lublin, Poland.
Purpose: Renal cell carcinoma (RCC) is the fourth most common metastatic tumour of the spine. RCC metastases are highly vascular and might cause life-threatening intraoperative bleeding. That is why preoperative embolisation is performed to reduce intraoperative blood loss.
View Article and Find Full Text PDFLysosomal damage sensing and lysophagy initiation by SPG20-ITCH.
Mol Cell
April 2024
Center of Medical Biotechnology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany. Electronic address:
Cells respond to lysosomal membrane permeabilization by membrane repair or selective macroautophagy of damaged lysosomes, termed lysophagy, but it is not fully understood how this decision is made. Here, we uncover a pathway in human cells that detects lipid bilayer perturbations in the limiting membrane of compromised lysosomes, which fail to be repaired, and then initiates ubiquitin-triggered lysophagy. We find that SPG20 binds the repair factor IST1 on damaged lysosomes and, importantly, integrates that with the detection of damage-associated lipid-packing defects of the lysosomal membrane.
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