Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Psychotropic medications: a descriptive study of prescription trends in Tabriz, Iran, 2021-2022.
BMC Psychiatry
January 2025
Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
Introduction: Mental disorders, such as anxiety and depression, significantly impacted global populations in 2019 and 2020, with COVID-19 causing a surge in prevalence. They affect 13.4% of the people worldwide, and 21% of Iranians have experienced them.
View Article and Find Full Text PDFNonsedating anxiolytics.
Pharmacol Biochem Behav
December 2024
RespireRx Pharmaceuticals Inc., Glen Rock, NJ, USA.
Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABA-receptor (GABAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and alprazolam. While the GABAR PAMs possess remarkable anxiolytic efficacy, they have fallen out of favor due to a host of adverse effects including sedation, motor impairment, addictive potential and tolerance development.
View Article and Find Full Text PDFGreener analysis of eleven basic drugs in blood and urine using carbowax 20M based biofluid sampler (BFS) device.
J Chromatogr B Analyt Technol Biomed Life Sci
October 2024
Institute of Forensic Science & Criminology, Panjab University, Chandigarh 160014, India. Electronic address:
Article Synopsis
- * The BFS allows for the collection of biological samples without dilution or pre-treatment, with analytes successfully back-extracted for analysis using gas chromatography-mass spectrometry (GC-MS).
- * The method demonstrated good precision and recovery rates, making it suitable for forensic toxicology applications, while also being evaluated for its environmentally friendly characteristics.
Development of a nanocomposite hydrogel catalyzed HO/TMB system for determination of chlordiazepoxide in exhaled breath condensate.
RSC Adv
September 2024
Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences Tabriz Iran
In this study, an enzyme mimic catalyzed HO-tetramethylbenzidine system based on UiO-66/Au NPs-PVA nanocomposite hydrogel was employed as an optical probe for chlordiazepoxide sensing. An excellent detection limit of 0.0032 μg mL with a linear range of 0.
View Article and Find Full Text PDFChlordiazepoxide reduces anxiety-like behavior in the adolescent mouse elevated plus maze: A pharmacological validation study.
Pharmacol Biochem Behav
September 2024
Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA. Electronic address:
This report evaluates the effects of chlordiazepoxide, a benzodiazepine commonly prescribed to manage anxiety-related disorders in adolescent/pediatric populations, on elevated plus maze (EPM) performance in juvenile mice. This approach was taken because chlordiazepoxide produces anxiolytic-like effects in multiple models in adult rodents, however, less is known about the behavioral effects of this benzodiazepine in juveniles. Thus, we administered a single intraperitoneal injection of chlordiazepoxide (0, 5, or 10 mg/kg) to postnatal day 35 male C57BL/6 mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!