A differentiated approach to the choice of criterion of reliability in toxicological studies is recommended. This approach is based on quantitative assessment of variability of biological parameters using the variation coefficient. All biological parameters are classified into rigid, flexible and high-flexible ones. The establishment of the biological significance of various parameters and assessment of the degree of their deviation allows the detection of prepathological changes in the body state, this being of importance for a more accurate LOAEL and NOAEL determination.
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| http://dx.doi.org/10.1016/0378-4274(92)90101-o | DOI Listing |
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