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Metabolic profiles of cutaneous lupus have abnormalities in the nicotinamide adenine dinucleotide pathway.
Lupus Sci Med
January 2025
Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
Objective: Metabolic reprogramming plays a critical role in modulating the innate and adaptive immune response, but its role in cutaneous autoimmune diseases, such as cutaneous lupus erythematosus (CLE), is less well studied. An improved understanding of the metabolic pathways dysregulated in CLE may lead to novel treatment options, biomarkers and insights into disease pathogenesis. The objective was to compare metabolomic profiles in the skin and sera of CLE and control patients using liquid chromatography-mass spectrometry (LC-MS).
View Article and Find Full Text PDFPrimary versus Secondary Immune Thrombocytopenia (ITP): A Meeting Report from the 2023 McMaster ITP Summit.
Thromb Haemost
January 2025
Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada.
The McMaster Immune Thrombocytopenia (ITP) Summit, held on October 27, 2023, was an educational seminar from leading experts in immune thrombocytopenia and related disorders geared toward hematologists, internists, immunologists, and clinical and translational scientists. The focus of the Summit was to review the mechanisms, diagnosis, and treatment of primary versus secondary ITP. Specific objectives were to describe the unique features of secondary ITP, and to review its mechanisms in the context of autoimmune disease and infection.
View Article and Find Full Text PDFArticle Synopsis
- Thyroid and salivary gland cytopathology often present diagnostic challenges due to overlapping features and rare conditions, prompting a focused seminar at the 45th European Congress of Cytology to address these issues.
- The seminar showcased complex cases using fine-needle aspiration cytology (FNAC) alongside histopathological and molecular analyses to differentiate between benign and malignant lesions.
- The findings emphasize the necessity of a comprehensive, multidisciplinary diagnostic approach that integrates cytological, clinical, and histopathological data for accurate patient management.
Saving Legs & Lives: the efficacy of a community-based cardiovascular rehabilitation programme versus usual care on exercise capacity and quality of life in patients who have undergone lower limb revascularisation for peripheral arterial disease-protocol for a single-centre randomised-controlled trial.
BMJ Open
December 2024
School of Health, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.
Article Synopsis
- Peripheral artery disease (PAD) causes narrowed arteries in the legs, leading to leg pain during walking, which hampers daily activities; supervised exercise can help improve walking ability.
- This study will compare a cardiovascular rehabilitation (CR) program involving supervised exercise and education with usual care in 66 patients who have recently undergone lower limb revascularisation for PAD.
- The effectiveness of the CR program will be evaluated based on improvements in walking capacity and quality of life over a 6-week period.
Fall Risk and Medication Use Near End of Life Among Adults With Chronic Obstructive Pulmonary Disease.
Chronic Obstr Pulm Dis
November 2024
Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington, United States.
Article Synopsis
- - Falls are a common and serious issue for individuals with chronic obstructive pulmonary disease (COPD), leading to higher rates of illness, death, and health care costs; identifying medication factors that increase fall risk is critical for prevention strategies.
- - A study analyzed health records of over 8,200 COPD patients who died between 2014-2018, finding that 30% had experienced an injurious fall in the two years prior, with 65% taking fall-risk increasing drugs (FRIDs).
- - The research indicates a higher likelihood of falls among patients prescribed certain medications like anticonvulsants and antipsychotics, suggesting a need for collaboration among healthcare providers to review and adjust medication use for better safety outcomes.
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