Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Viroporin activity is necessary for intercellular calcium signals that contribute to viral pathogenesis.
Sci Adv
January 2025
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
Viruses engage in a variety of processes to subvert host defenses and create an environment amenable to replication. Here, using rotavirus as a prototype, we show that calcium conductance out of the endoplasmic reticulum by the virus encoded ion channel, , induces intercellular calcium waves that extend beyond the infected cell and contribute to pathogenesis. Viruses that lack the ability to induce this signaling show diminished viral shedding and attenuated disease in a mouse model of rotavirus diarrhea.
View Article and Find Full Text PDFReduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease.
Physiol Rep
January 2025
Developmental Biology and Cancer Research and Teaching Department, University College London, Great Ormond Street Institute of Child Health, London, UK.
Polycystic kidney diseases (PKD) are genetic disorders which disrupt kidney architecture and function. Autosomal recessive PKD (ARPKD) is a rare form of PKD, caused by mutations in PKHD1, and clinically more severe than the more common autosomal dominant PKD (ADPKD). Prior studies have implicated Hedgehog (Hh) signaling in ADPKD, with increased levels of Hh components in experimental ADPKD and reduced cystogenesis following pharmacological Hh inhibition.
View Article and Find Full Text PDFToxoplasmosis is a significant food-borne protozoal disease in humans and animals. The study aimed to find out Toxoplasma seropositivity in sheep, estimate epidemiological risk factors and assess haemato-biochemical parameter changes. Blood samples were collected from 276 indigenous sheep in five districts surrounding Sulaymaniyah Province in the northern region of Iraq.
View Article and Find Full Text PDFDifferential recruitment drives pathogen-mediated competition between species in an amphibian chytridiomycosis system.
Ecol Appl
January 2025
Centre for Planetary Health and Food Security, and School of Environment and Science, Griffith University, Southport, Queensland, Australia.
Pathogens that infect multiple host species have an increased capacity to cause extinctions through parasite-mediated apparent competition. Given unprecedented and continuing losses of biodiversity due to Batrachochytrium dendrobatidis (Bd), the causative fungus of the amphibian skin disease chytridiomycosis, a robust understanding of the mechanisms driving cross-species infection dynamics is essential. Here, we used stage-structured, susceptible-infected compartmental models to explore drivers of Bd-mediated apparent competition between two sympatric amphibians, the critically endangered Litoria spenceri and the non-threatened Litoria lesueurii.
View Article and Find Full Text PDFUSP7 Inhibitors Destabilize EBNA1 and Suppress Epstein-Barr Virus Tumorigenesis.
J Med Virol
January 2025
The Wistar Institute, Philadelphia, Pennsylvania, USA.
Epstein-Barr virus (EBV) is a ubiquitous human ɣ-herpesvirus implicated in various malignancies, including Burkitt's lymphoma and gastric carcinomas. In most EBV-associated cancers, the viral genome is maintained as an extrachromosomal episome by the EBV nuclear antigen-1 (EBNA1). EBNA1 is considered to be a highly stable protein that interacts with the ubiquitin-specific protease 7 (USP7).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!