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Comparative Evaluation of Aminoguanidine, Semicarbazide and Thiosemicarbazide Treatment for Methylglyoxal-Induced Neurological Toxicity in Experimental Models.
Iran J Pharm Res
October 2024
Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Advanced glycation end products (AGEs), mainly derived from methylglyoxal (MG), are linked to neurological disorders such as Alzheimer's disease.
- The study assessed the effects of aminoguanidine (AG), semicarbazide (SC), and thiosemicarbazide (TSC) on MG-induced toxicity in rats, revealing that MG exposure led to memory issues, increased anxiety, and brain cell damage.
- Semicarbazide showed the most promise in preventing memory problems, while AG and TSC alleviated anxiety and improved neuronal survival in specific brain regions affected by MG.
- Further research is needed to understand how these compounds protect against neurobehavioral toxicity.
A comparative study on the antioxidant and antiglycation properties of different vitamin D forms.
Eur J Med Chem
January 2025
Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 2c Mickiewicza Street, 15-233, Bialystok, Poland. Electronic address:
Vitamin D plays multiple roles in the body. Recently, there has been an increase in its popularity and growing interest in vitamin D supplementation. However, the mechanisms of vitamin D action have not yet been sufficiently explored.
View Article and Find Full Text PDFAminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.
Skelet Muscle
January 2025
Department of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Background: Duchenne muscular dystrophy (DMD) is a prevalent, fatal degenerative muscle disease with no effective treatments. Mdx mouse model of DMD exhibits impaired muscle performance, oxidative stress, and dysfunctional autophagy. Although antioxidant treatments may improve the mdx phenotype, the precise molecular mechanisms remain unclear.
View Article and Find Full Text PDF5,7-Dihydroxyflavone acts on eNOS to achieve hypotensive effects in spontaneously hypertensive rats.
Sci Rep
January 2025
Anatomy Department, College of Basic Medical Science, Xiamen Medical College, Xiamen, Fujian, China.
Hypertension is one of the most serious chronic diseases. This study will focus on the systemic antihypertensive mechanisms of 5,7-dihydroxyflavone from in silico simulations to in vivo validations. In-silico studies were applied by network pharmacology, molecular docking, and molecular dynamic simulation.
View Article and Find Full Text PDFAn Intermediate-Aided Perovskite Phase Purification for High-Performance Solar Cells.
J Am Chem Soc
January 2025
Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.
In recent years, perovskite solar cells (PSCs) have garnered considerable attention as a prime candidate for next-generation photovoltaic technology. Ensuring the structural stability of perovskites is crucial to the operational reliability of these devices. However, the nonphotoactive yellow phase (δ-FAPbI) of formamidine (FA)-based perovskites is more favorable in thermodynamics, making it challenging to achieve pure α phase in crystallization.
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