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Pseudobulbar affect: clinical associations, social impact and quality of life implications - Lessons from PLS.
J Neurol
March 2025
Computational Neuroimaging Group (CNG), School of Medicine, Trinity College, Pearse Street, Dublin, Ireland.
Background: Pseudobulbar affect (PBA) is a well-recognised and troublesome clinical phenomenon in a range of neuroinflammatory, neoplastic, neurovascular and neurodegenerative conditions. It is often under-recognised in the community, frequently mistaken for psychiatric manifestations, appropriate pharmacological treatment is often delayed, and may result in a sense of embarrassment or lead to social isolation. Despite its considerable quality of life (QoL) implications and the challenges associated with its effective management, it is notoriously understudied.
View Article and Find Full Text PDFThe purpose of this study is to describe the prevalence of problematic feeding in the first 6 months of life in infants born preterm, the impact of feeding problems on the family and parent, and explore which factors known at the time of neonatal discharge predict later symptoms of problematic feeding. The study design is a longitudinal, observational study. The sample included 43 infants born at 28.
View Article and Find Full Text PDFSafety and efficacy of proton pump inhibitors in preterm infants with gastroesophageal reflux disease.
Cochrane Database Syst Rev
March 2025
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Background: Although physiological reflux is seen in nearly all newborns to varying degrees, symptoms can be severe and cause gastroesophageal reflux disease (GERD). In preterm infants, one symptom that is often attributed to GERD is apnea and associated cardiorespiratory events, such as bradycardia and oxygen desaturation. Although the relationship between GERD and apnea, bradycardia, and desaturation events remains a subject of ongoing investigation, trials of agents that reduce gastric acidity, such as proton pump inhibitors (PPI), have been conducted to assess the effect of these agents on GERD.
View Article and Find Full Text PDFDoes swallow rehabilitation improve recovery of swallow function after treatment for advanced head and neck cancer.
Sci Rep
March 2025
Department of Otorhinolaryngology, China Medical University Hospital, No. 2, Yude Rd., North Dist, Taichung, 404327, Taiwan (R.O.C.).
This study aimed to assess the prevalence, severity, and progression of swallowing impairments in head and neck cancer (HNC) patients before and after treatment, using videofluoroscopy with the Modified Barium Swallow Impairment Profile (MBSImP) protocol. We retrospect survey 90 HNC patients was divided into rehabilitation (receiving swallowing rehabilitation) and non-rehabilitation groups. All participants underwent a videofluoroscopic swallowing study with MBSImP, the Penetration-Aspiration Scale (PAS), and the Swallowing Performance Status (SPS) scale, along with assessments using the EAT-10 and Functional Oral Intake Scale (FOIS) at baseline, and at 1 and 3 months post-treatment.
View Article and Find Full Text PDFClinical Reasoning: A 56-Year-Old Woman With New-Onset Hoarseness and Dysphagia.
Neurology
April 2025
Department of Neurology, NYU Grossman School of Medicine, NY.
Statement Of The Clinical Problem Addressed By The Case: We report an atypical clinical presentation of a rapidly progressive neurologic emergency that required prompt investigation and treatment of impending respiratory failure. We discuss the differential diagnosis, evaluation, emergency management, and treatment options of patients with atypical variants of this disorder.
Brief Description Of Case Presentation: A 56-year-old woman with a history of hypothyroidism, anxiety, and depression presented to the emergency department 3 weeks after an upper respiratory and ear infection with cough, pain with sinus palpation, tingling in her fingers bilaterally and right foot, hives, and an episode of blurry vision on awakening.
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