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Neutrophil depletion enhanced the -NT therapy in mouse and rabbit tumor models.
Neurooncol Adv
December 2021
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: Hypoxia is a prominent feature of solid tumors and can function as fertile environment for oncolytic anaerobic bacteria such as -NT (-NT) where it can induce tumor destruction in mice and patients. However, two major obstacles have limited its use, namely the host inflammatory response and the incomplete clearance of normoxic tumor areas.
Methods: In this study, we first used a subcutaneous tumor model of a glioblastoma (GBM) cell line in immunocompetent mice to investigate the local distribution of tumor hypoxia, kinetics of -NT germination and spread, and the local host immune response.
Novel insights into the role of Clostridium novyi-NT related combination bacteriolytic therapy in solid tumors.
Oncol Lett
February 2021
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China.
Several solid tumors (for example leiomyosarcoma, melanoma and hepatocellular carcinoma) possess areas of hypoxia, which underlies one of the primary reasons of failure of conventional anticancer therapies. The areas of poor vascularization are insensitive to radiotherapy and chemotherapeutic drugs. Conversely, the hypoxic regions of tumors provide an ideal environment for anaerobic bacteria.
View Article and Find Full Text PDFThe Dosage of the Derivative of (DCG) Spores Dictates Whether an IFN/IL-9 or a Strong IFN Response Is Elicited in TC-1 Tumour Bearing Mice.
Biomed Res Int
December 2019
School of Medical Science and Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4333, Australia.
Background: Anaerobic spores (CG) cause significant oncolysis in hypoxic tumour microenvironment and result in tumour regression in both animal models and clinical trials. The immune mediated response plays a critical role in the antitumour effect by the anaerobic spore treatment.
Method: Human papillomavirus 16 E6/E7 transformed TC-1 tumour bearing mice were intravenously administered with low (1 × 10 CFU/kg) or high dosage (3 × 10 CFU/kg) of Derivative spore (DCG).
Pathogens and glioma: a history of unexpected discoveries ushering in novel therapy.
J Neurosurg
April 2018
2Cell Biology, and.
In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy.
View Article and Find Full Text PDFClostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats.
Oncotarget
March 2015
Department of Neurology & Neurosurgery, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Glioblastoma (GBM) is a highly aggressive primary brain tumor that is especially difficult to treat. The tumor's ability to withstand hypoxia leads to enhanced cancer cell survival and therapy resistance, but also yields a microenvironment that is in many aspects unique within the human body, thus offering potential therapeutic opportunities. The spore-forming anaerobic bacterium Clostridium novyi-NT(C.
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