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Development and optimization of a new competitive ELISA using recombinant (rPSA D15 and rCag11) antigens for the detection of Helicobacter pylori infection.
PLoS One
January 2025
Kenya Medical Research Institute, Centre for Microbiology Research, Nairobi, Kenya.
H. pylori (Hp) is highly causative agent of chronic gastritis, gastric cancer and human death worldwide. To address the challenge of H.
View Article and Find Full Text PDFDescription of sp. nov., isolated from pig faeces.
Int J Syst Evol Microbiol
January 2025
ABS Research Support Center, KRIBB, 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea.
Two Gram-stain-negative cocci anaerobes were isolated from pig faeces and designated as strains YH-vei2232 and YH-vei2233. Phylogenetic analysis using 16S rRNA gene sequences revealed that the isolates were most closely related to KCTC 5967, with 97.0% similarity.
View Article and Find Full Text PDFExploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells.
Heliyon
January 2025
Department of Zoology, The University of Burdwan, West Bengal, India.
Thalassemia is a hematological disorder caused by mutations in the hemoglobin gene, often necessitating regular blood transfusions. These frequent transfusions exert continuous pressure on patients' immune systems. Despite extensive research on the hematological aspects of thalassemia, few studies have explored the immune status of these patients.
View Article and Find Full Text PDFMolecular characterization and bioinformatic analysis of SGU protein in Anopheles culicifacies as target for transmission blocking activity.
Immunol Res
January 2025
Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, India.
In tropical countries, malaria transmission is the major health issue. To eradicate malaria, health communities depend on the control measure that affects economy and environment of the countries. To overcome these burdens, there is a great need to develop vaccine against malaria, but there is no vaccine to control malaria effectively.
View Article and Find Full Text PDFClade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice.
Nat Commun
January 2025
Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared to produce millions of vaccine doses to address an H5N1 pandemic, currently circulating H5N1 viruses contain multiple mutations within the immunodominant head domain of hemagglutinin (HA) compared to the antigens used in stockpiled vaccines. It is unclear if these stockpiled vaccines will need to be updated to match the contemporary H5N1 strains.
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