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Cardiovascular Disease Risk in South Asians in the Baylor Scott and White Health DILWALE Registry.
JACC Adv
December 2024
Johns Hopkins Department of Internal Medicine, Baltimore, Maryland, USA.
Background: Despite implementation of preventive interventions targeting cardiovascular disease (CVD), atherosclerotic CVD (ASCVD) remains a major public health concern in the South Asian (SA) population.
Objectives: The purpose of this study was to assess the risk factor prevalence and ASCVD outcomes in SA population in the United States.
Methods: The DIL Wellness and Arterial health Longitudinal Evaluation registry collected data retrospectively on SA adult patients receiving care in the Baylor Scott & White Healthcare system.
Bufadienolides from Chansu Injection Synergistically Enhances the Antitumor Effect of Erlotinib by Inhibiting the KRAS Pathway in Pancreatic Cancer.
Pharmaceuticals (Basel)
December 2024
Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Ministry of Education, Shihezi University School of Medicine, Shihezi 832003, China.
The Chansu injection (CSI), a sterile aqueous solution derived from Chansu, is applied in clinical settings to support antitumor and anti-radiation treatments. CSI's principal active components, bufadienolides (≥90%), demonstrate potential effects on pancreatic cancer (PDAC), but their underlying mechanisms remain unclear. This study aimed to elucidate the antitumor effects and pathways associated with CSI in PDAC.
View Article and Find Full Text PDFTraumatic obturator dislocation of the hip associated with ipsilateral subtrochanteric femur fracture in a young adult: a case report.
J Med Case Rep
December 2024
Department of Internal Medicine, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Introduction: Traumatic obturator-type anterior dislocation of the hip with an ipsilateral subtrochanteric fracture is rarely encountered in clinical practice. This case presentation described a trauma patient with such a rare scenario.
Case Report: This paper reports a case of a 20-year-old Amhara ethnic male patient who had a traumatic anterior dislocation of the hip associated with an ipsilateral subtrochanteric femur fracture after a truck rolled over.
Hydrazone copper(II) complexes suppressed lung adenocarcinoma by activating multiple anticancer pathway.
Bioorg Chem
January 2025
The Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China; Key Laboratory of Basic Research on Respiratory Diseases, Guangxi Health Commission, Guilin, Guangxi, China. Electronic address:
Article Synopsis
- Researchers created four new copper(II) hydrazone complexes to assess their potential in treating lung cancer.
- The MTT assays indicated that these complexes, especially complex 3, were more effective against cancer cells than the common drug cisplatin, showing selective toxicity towards A549 lung cancer cells.
- Complex 3 not only demonstrated low toxicity in normal cells but also effectively killed tumor cells through multiple anticancer pathways, including a process called cuproptosis, confirming its potential for lung cancer treatment in experiments with mice.
A cross-sectional study of physiologic volar melanotic macules: Demographic, historical, clinical, and dermatoscopic features of a common yet neglected pigmentary variant in individuals with skin of color.
J Am Acad Dermatol
November 2024
Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts. Electronic address:
Background: Physiologic volar melanotic macules (P-VMM) are understudied. Trauma has been suggested as a predisposing factor. Little has been published over the last several decades.
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