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Prescribing of clotrimazole-betamethasone dipropionate, a topical combination corticosteroid-antifungal product, for Medicare part D beneficiaries, United States, 2016-2022.
Antimicrob Steward Healthc Epidemiol
October 2024
Centers for Disease Control and Prevention, Atlanta, GA, USA.
During 2016-2022, Medicare part D beneficiaries filled 8,674,460 clotrimazole-betamethasone dipropionate prescriptions. Annual rates were stable (30.9 prescriptions/1,000 beneficiary-years in 2022, enough for one in every 33 beneficiaries).
View Article and Find Full Text PDFCorticosteroids for the Treatment of Internal Temporomandibular Joint Disorders: A Systematic Review and Network Meta-Analysis.
J Clin Med
August 2024
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada.
We evaluated the comparative effectiveness of all intra-articular injection corticosteroids for treating internal temporomandibular joint (TMJ) disorders. : We searched MEDLINE, CENTRAL, EMBASE, SCOPUS, and LILACS through December 2023. We included randomized clinical trials (RCTs) enrolling patients with symptomatic internal disorders of the TMJ comparing any type of intra-articular corticosteroid therapy against another or to another minimally invasive therapy.
View Article and Find Full Text PDFAnterior Uveitis After Discontinuation of Janus Kinase Inhibitor, Ruxolitinib.
J Med Cases
August 2024
Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama City 700-8558, Japan.
Primary myelofibrosis shows widespread fibrosis in the bone marrow and is part of myeloproliferative neoplasms in which gene mutations in hematopoietic stem cells lead to abnormal clonal expansion of one or more lineage of myeloid and erythroid cells and megakaryocytes. Janus kinase (JAK) inhibitors are the main therapeutic regimen for primary myelofibrosis which harbors gene mutations, resulting in continuous activation of JAK-STAT signaling pathway. Since JAK inhibitors modulate immunological state, the administration would have a potential for uveitis.
View Article and Find Full Text PDFDevelopment of UPLC-MS/MS method for the simultaneous quantification of valproic acid and phenytoin in human plasma and application to study pharmacokinetic interaction in epilepsy patients.
Heliyon
July 2024
Department of Analytical Chemistry - Toxicology - Drug Quality Control, Faculty of Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho, 900000, Viet Nam.
Article Synopsis
- Valproic acid and phenytoin, common antiepileptic drugs, have narrow therapeutic indices and can cause cardiovascular and respiratory toxicity, making therapeutic drug monitoring (TDM) crucial for patient safety and treatment effectiveness.
- A sensitive ultra-performance liquid chromatographic tandem mass spectrometer (UPLC-MS/MS) method was developed to simultaneously measure VAL and PHE in human plasma, using specific ionization techniques for accurate quantification.
- The method demonstrated high recovery rates and met all US-FDA bioanalytical validation criteria, successfully evaluating the drug levels in plasma from epileptic patients.
Diagnostic Capability of Intra-Articular Injections for Femoroacetabular Impingement Syndrome: A Systematic Review.
Clin J Sport Med
November 2024
Internal Medicine Department, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil .
Objective: To review and critically appraise available literature concerning the diagnostic capability of intra-articular injections for femoroacetabular impingement (FAI) syndrome.
Design: Systematic review.
Setting: N/A.
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