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Preoperative survey to evaluate the patients' allergy list and its relevance to perioperative care.
Paediatr Anaesth
October 2024
Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Introduction: Perioperative hypersensitivity and allergic reactions can result in significant morbidity and mortality. For routine anesthetic care, allergies are determined from a review of the electronic medical record supplemented by a detailed patient history. Although the electronic medical record is generally assumed to be accurate, it may be that allergies are erroneously listed or not based on sound medical practice.
View Article and Find Full Text PDFAssessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in models of mast cell degranulation and red blood cell hemolysis.
Biochem Biophys Rep
September 2022
Perron Institute for Neurological and Translational Sciences, First Floor, RR-Block, QEII Medical Centre, Nedlands, Western Australia, Australia.
Our laboratory focuses on the development of novel neuroprotective cationic peptides, such poly-arginine-18 (R18: 18-mer of l-arginine; net charge +18) and its d-enantiomer R18D in stroke and other brain injuries. In the clinical development of R18/R18D, their cationic property raises potential safety concerns on their non-specific effects to induce mast cell degranulation and hemolysis. To address this, we first utilised primary human cultured mast cells (HCMCs) to examine anaphylactoid effects.
View Article and Find Full Text PDFFailure of Risk Assessment After Paracetamol Overdose-A Short Communication.
Ther Drug Monit
April 2023
Laboratoire de Pharmacologie, Toxicologie et Gaz du Sang, CHU de Saint Etienne, France.
Background: The accepted treatment for patients with acetaminophen/paracetamol overdose includes risk assessment based on the Rumack-Matthew (R-M) nomogram. An inaccurate use of the nomogram may result in improper treatment. Clinicians were surveyed to determine their understanding and proper use of this risk assessment tool in practice.
View Article and Find Full Text PDFToxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.
Arch Toxicol
August 2021
Molecular Immunology Unit, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, Sydney, NSW, 2070, Australia.
Opioid-induced respiratory depression is potentially life-threatening and often regarded as the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia and hypercapnia. Respiratory depression is mediated by opioid μ receptors expressed on respiratory neurons in the CNS.
View Article and Find Full Text PDFSafety of traditional Chinese medicine injection based on spontaneous reporting system from 2014 to 2019 in Hubei Province, China.
Sci Rep
April 2021
Tongji Medical College, School of Medicine and Health Management, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China.
Traditional Chinese medicine (TCM) injection is widely used in clinical settings, but its adverse drug reactions (ADRs) can be a serious public health concern. The objective is to study the safety of TCM injection and provide suggestions for clinical use. ADR reports collected by the Hubei Adverse Drug Reaction Monitoring Center from 2014 to 2019 were analysed.
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