A 66-year-old male developed lymphocytic alveolitis with bronchiolitis after 3 month's treatment with mesalazin for ulcerative colitis. The patient's symptoms disappeared after halting mesalazin and increasing the steroid dose, the reduced diffusing capacity ameliorated and the thoracic X-ray normalized. The question whether this was a case of pulmonary involvement in inflammatory bowel disease or a drug side effect.
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German recommendations for the diagnosis of hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis (EAA), were last published in 2007 [1]. The current S2k Guideline for the Diagnosis and Treatment of Hypersensitivity Pneumonitis (HP) replaces these diagnostic recommendations. They were supplemented by the aspect of chronic, and in particular of the chronic fibrotic phenotype of HP, and also, as first HP guideline, include treatment recommendations.
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BMJ Case Rep
January 2025
Pneumology, Centre Hospitalier du Valais Romand, Sion, Switzerland.
A woman in her mid-70s presented with worsening dyspnoea, cough and fatigue initially treated for pneumonia. Despite antibiotics, her condition deteriorated, prompting further investigation. Medical history included previous breast implants, the latter of which had ruptured years earlier and was subsequently removed prior to the current presentation.
View Article and Find Full Text PDFPost-COVID-19 Trends in Dental Emergencies: A Two-Year Retrospective Study from Romania.
Dent J (Basel)
December 2024
Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, 10 Piața 1 Decembrie Street, 410073 Oradea, Romania.
: Dental emergencies significantly impact public oral health, particularly in the post-COVID-19 context. This study aimed to analyze the patterns of dental emergencies presenting to the Emergency Dental Service in Bihor, Romania, during the years 2022 and 2023, focusing on demographic characteristics and the frequency of diagnoses. : A retrospective analysis of medical records from the Emergency Dental Service at Oradea County Emergency Clinical Hospital was conducted.
View Article and Find Full Text PDFProtein kinase D1 in myeloid lineage cells contributes to the accumulation of CXCR3CCR6 nonconventional Th1 cells in the lungs and potentiates hypersensitivity pneumonitis caused by .
Front Immunol
October 2024
Integrated Biomedical Science Graduate Program, The University of Tennessee Health Science Center, Memphis, TN, United States.
Article Synopsis
- Hypersensitivity pneumonitis (HP) is an allergic lung condition characterized by inflammation and granuloma formation; recent studies suggest that protein kinase D1 (PKD1) in lungs contributes to its acute inflammation and IL-17A expression.
- The study utilized mouse models exposed to specific allergens to examine the effects of PKD1 in myeloid-lineage cells on HP development by measuring immune responses and tissue changes.
- Results indicated that mice lacking PKD1 in myeloid cells showed reduced inflammation and cytokine levels, leading to less lung damage and immune cell accumulation compared to normal mice, highlighting PKD1’s importance in HP progression.
[Medical clinical diagnostics for indoor mould exposure - Update 2023 (AWMF Register No. 161/001)].
Pneumologie
October 2024
Labor Dr. Wisplinghoff.
This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case of indoor mould exposure - Update 2023", presented in July 2023 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with German and Austrian scientific medical societies, and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. There is no evidence for a causal relationship between moisture/mould damage and human diseases, mainly because of the ubiquitous presence of fungi and hitherto inadequate diagnostic methods.
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