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Fatty Acid Synthase (FASN) Inhibitors Suppress Metformin-Induced Fat Accumulation and Apoptosis in H4IIE Hepatocellular Carcinoma Cells.
Dev Reprod
December 2024
Department of Histology, Jeju National University College of Medicine, Jeju 63243, Korea.
We previously reported that metformin, a widely prescribed antidiabetic drug, induces the accumulation of triglyceride (TG) together with the apoptotic death of H4IIE via AMP-activated protein kinase (AMPK) in hepatocellular carcinoma (HCC) cells. However, the effect of cytoplasmic fat accumulation on the growth of HCCs remains controversial. Herein, we investigated the effect of fatty acid synthase (FASN) inhibitors on the basal- or metformin-induced changes including the content of cytoplasmic TG and the viability of HCC cells.
View Article and Find Full Text PDFEngineering an Escherichia coli strain for enhanced production of flavonoids derived from pinocembrin.
Microb Cell Fact
November 2024
Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Article Synopsis
- Researchers improved pinocembrin production in E. coli by enhancing the supply of necessary building blocks, achieving 353 mg/L without additional precursor requirements.
- They found specific enzymes that increased production of related flavonoids, including chrysin and pinostrobin, with the highest yields coming from selected candidate enzymes from different plant sources.
A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA.
bioRxiv
September 2024
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Malonyl-CoA is the essential building block of fatty acids and regulates cell function through protein malonylation and allosteric regulation of signaling networks. Accordingly, the production and use of malonyl-CoA is finely tuned by the cellular energy status. Most studies of malonyl-CoA dynamics rely on bulk approaches that take only a snapshot of the average metabolic state of a population of cells, missing out on dynamic changes in malonyl-CoA and fatty acid biosynthesis that could be occurring within a single cell.
View Article and Find Full Text PDFFatty acid synthase inhibitor cerulenin hinders liver cancer stem cell properties through FASN/APP axis as novel therapeutic strategies.
J Lipid Res
November 2024
Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
Hepatocellular carcinoma (HCC) poses significant treatment challenges due to high postoperative recurrence rates and the limited effectiveness of targeted medications. Researchers have identified the unique metabolic profiles of cancer stem cells (CSCs) as the primary drivers of cancer recurrence, metastasis, and drug resistance. Therefore, to address the therapeutic conundrum, this study focused on rewinding metabolic reprogramming of CSCs as a novel therapeutic strategy.
View Article and Find Full Text PDFThe Inhibitory Effects of Maclurin on Fatty Acid Synthase and Adipocyte Differentiation.
Int J Mol Sci
August 2024
Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Obesity is a complex health condition characterized by excessive adipose tissue accumulation, leading to significant metabolic disturbances such as insulin resistance and cardiovascular diseases. Fatty acid synthase (FAS), a key enzyme in lipogenesis, has been identified as a potential therapeutic target for obesity due to its role in adipocyte differentiation and lipid accumulation. This study employed a multidisciplinary approach involving in silico and in vitro analyses to investigate the anti-adipogenic properties of maclurin, a natural phenolic compound derived from .
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