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Development of Stabilized and Aqueous Dissolvable Nanosuspension Encompassing BCS Class IV Drug via Optimization of Process and Formulation Variables.
Recent Pat Nanotechnol
January 2025
Raj Kumar Goel Institute of Technology (Pharmacy), 5-Km. Stone, Delhi-Meerut Road, Ghaziabad, Uttar Pradesh, India.
Background: Nanosuspension has emerged as an effective, lucrative, and unequalled approach for efficiently elevating the dissolution and bioavailability of aqueous soluble drugs. Diverse challenges persist within this domain, demanding further comprehensive investigation and exploration.
Objective: This study aims to design, develop, optimise formulation and process variables, and characterise the stabilised aqueous dissolvable nanosuspension using chlorthalidone as a BCS class- IV drug.
Chlorthalidone vs Hydrochlorothiazide and Kidney Outcomes in Patients With Hypertension: A Secondary Analysis of a Randomized Clinical Trial.
JAMA Netw Open
December 2024
Cooperative Studies Program Coordinating Center, VA Boston Healthcare System, Boston, Massachusetts.
Importance: Hypertension is a risk factor for the development and progression of chronic kidney disease (CKD). It is unclear whether different thiazide diuretics have a differential impact on kidney outcomes.
Objective: To compare kidney outcomes in patients with hypertension taking chlorthalidone and hydrochlorothiazide.
Efficacy and Safety of Chlortalidone and Hydrochlorothiazide in Prevention of Cardiovascular Diseases.
Rev Cardiovasc Med
October 2024
Department of Cardiovascular Medicine, Peking Union Medical College Hospital, 100730 Beijing, China.
Background: The variance between guideline recommendations and real-world usage might stem from the perception that chlorthalidone poses a higher risk of adverse effects, although there is no clear evidence of disparities in cardiovascular outcomes. It is crucial to assess both the clinical cardiovascular effects and adverse reactions of both drugs for clinical guidance. In this study, we present a comprehensive and updated analysis comparing the efficacy and safety of chlorthalidone (CHLOR) versus hydrochlorothiazide (HCTZ) for the prevention of cardiovascular diseases through lower the blood pressure.
View Article and Find Full Text PDF[The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.].
Recenti Prog Med
October 2024
Dipartimento di Cardiologia, Ospedale Santa Maria della Misericordia, Perugia.
The recent guidelines issued by the European Society of Hypertension reaffirmed that the degree of control of hypertension remains suboptimal worldwide. In order to increase the proportion of well-controlled patients, in addition to nonpharmacological measures, it is necessary to improve the implementation of drug therapy in the clinical practice as much as possible. Initial therapy should almost always be based on the combination, free or fixed, between ACE inhibitor drugs, or direct angiotensin II inhibitors ('sartans') and diuretics (thiazide or thiazide-like) or calcium channel blockers at the maximum recommended and well-tolerated dose.
View Article and Find Full Text PDFUtility of a Systolic Blood Pressure Polygenic Risk Score With Chlorthalidone Response.
JAMA Cardiol
December 2024
Department of Epidemiology, University of Alabama at Birmingham.
Article Synopsis
- A study investigated how well a polygenic risk score (PRS) for systolic blood pressure (SBP) can predict patients' responses to antihypertensive treatment and the risk of treatment-resistant hypertension.
- The research focused on participants from the GenHAT study, specifically Black individuals who were assigned to treatment groups involving chlorthalidone or lisinopril.
- The main outcomes measured were changes in blood pressure after six months and the likelihood of being classified as treatment-resistant hypertension based on defined criteria.
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