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Role of tertiary lymphoid structures and B cells in clinical immunotherapy of gastric cancer.
Front Immunol
January 2025
Central Laboratory, Bayannur Hospital, Bayannur, Inner Mongolia, China.
Gastric cancer is a common malignant tumor of the digestive tract, and its treatment remains a significant challenge. In recent years, the role of various immune cells in the tumor microenvironment in cancer progression and treatment has gained increasing attention. Immunotherapy, primarily based on immune checkpoint inhibitors, has notably improved the prognosis of patients with gastric cancer; however, challenges regarding therapeutic efficacy persist.
View Article and Find Full Text PDFOccipital bone modeling patterns during the first years of life: A preliminary histological and quantitative approach.
J Anat
January 2025
Laboratorio de Evolución Humana, Universidad de Burgos, Burgos, Spain.
Studies of modeling processes have provided important insights in human evolutionary discipline. Most of these studies are based on facial bones and in much lesser extent on other bones such as those from the cranial vault. Thus, this study fills a gap in research by examining occipital bone modeling in subadults, adding individuals under 2 years old and expanding the sample size available to date.
View Article and Find Full Text PDFExpanding the Molecular Genetic Landscape of Dystrophinopathies and Associated Phenotypes.
Biomedicines
November 2024
Department of Pediatric Neurology, Centre for Neuromuscular Disorders, Centre for Translational Neuro- and Behavioral Sciences, University Duisburg-Essen, 45122 Essen, Germany.
: X-linked dystrophinopathies are a group of neuromuscular diseases caused by pathogenic variants in the gene (MIM *300377). Duchenne muscular dystrophy (DMD; MIM #310200) is the most common inherited muscular dystrophy. : We screened datasets of 403 male, genetically confirmed X-linked dystrophinopathy patients and identified 13 pathogenic variants of the gene that have not been described in the literature thus far.
View Article and Find Full Text PDFClinicopathological Features and Prognoses of Patients With Splenic Metastases From Breast Cancer: A Single-Centre, Retrospective Study.
Cancer Control
January 2025
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, P.R. China.
Purpose: Splenic metastases (SM) from breast cancer (SMBC) are exceedingly rare. To date, the relevant literature is primarily based on pan-tumour species, with only a few studies exploring SM specifically in relation to breast cancer. As such, the present retrospective study explored the clinicopathological characteristics and prognoses of patients with SMBC at the breast care centre of the authors' hospital.
View Article and Find Full Text PDFArtesunate remarkably alleviates interstitial cystitis/bladder pain syndrome in a murine model: Novel molecular signature deciphered by bulk tissue and single-cell transcriptomic analysis.
FASEB J
December 2024
Department of Urology, Zhejiang Cancer Hospital, Hangzhou, China.
Article Synopsis
- - Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain condition with unclear causes, which leads to lower urinary tract issues and has shown inconsistent treatment results due to its complex nature.
- - Researchers created a mouse model of IC/BPS using specific chemicals and tested the effects of artesunate (ART), finding significant symptom relief and histological improvements, alongside identifying key gene modules related to the condition.
- - The study reveals changes in immune cells related to IC/BPS and represents a pioneering approach using single-cell transcriptomics to understand the immune environment, suggesting ART's potential therapeutic role, although further patient-focused studies are necessary.
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