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Identification of f.a., sp. nov. and large indels in the rRNA cistron that split the genus.
Int J Syst Evol Microbiol
January 2025
National Fungal Culture Collection of India (NFCCI), Biodiversity and Palaeobiology Group, MACS-Agharkar Research Institute, Pune, India.
Yeast strains representing a novel asexual ascomycetous species were isolated from seven flowers. Sequencing of the chromosomal regions coding for the D1/D2 domains of the large subunit ribosomal RNA, the ITS1-5.8S-ITS2 segments and parts of the gene coding for the small subunit ribosomal RNA showed that the isolates were conspecific.
View Article and Find Full Text PDFTwo Different Brain Injury Patterns Associated with Compound Heterozygosis of the PIGO Gene in a Term Newborn: A Case Report.
Biomedicines
December 2024
Diagnostic and Interventional Neuroradiology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
The glycosylphosphatidylinositol (GPI) is a glycol-lipid that anchors several proteins to the cell surface. The GPI-anchor pathway is crucial for the correct function of proteins involved in cell function, and it is fundamental in early neurogenesis and neural development. The PIG gene family is a group of genes involved in this pathway with six genes identified so far, and defects in these genes are associated with a rare inborn metabolic disorder manifesting with a spectrum of clinical phenotypes in newborns and children.
View Article and Find Full Text PDFLithocholic Acid's Ionic Compounds as Promising Antitumor Agents: Synthesis and Evaluation of the Production of Reactive Oxygen Species (ROS) in Mitochondria.
Antioxidants (Basel)
November 2024
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russia.
The development of a methodology for the synthesis of new compounds with antitumor activity represents a significant and priority task within the field of medicinal chemistry. As a continuation of our research group's earlier studies on the antitumor activity of ionic derivatives of natural compounds, we have synthesized a series of previously undescribed pyrazole ionic compounds through a series of transformations of lithocholic acid methyl ester. To investigate the biological activity of the newly synthesized lithocholic acid derivatives, a series of modern flow cytometry techniques were employed to assess their cytotoxic activity, effects on the cell cycle, and induction of apoptosis.
View Article and Find Full Text PDFPregnane C21-Steroids with Anti-inflammatory Activity from the Roots of Cynanchum bungei.
Chem Biodivers
January 2025
Guangdong Medical University School of Pharmacy, School of Pharmacy, Xincheng Road, 523808, Dongguan, CHINA.
Article Synopsis
- Five new pregnane C21-steroids were identified from the roots of Cynanchum bungei, including three previously unknown 5,6-epoxy steroids and two 8,14-seco-steroids.
- Compound 3 is notable for being the first 5a,6a-epoxy steroid discovered in Cynanchum plants, with their structures confirmed through various spectroscopic methods and theoretical calculations.
- All isolated compounds showed anti-inflammatory properties by inhibiting nitric oxide release in RAW264.7 cells, with compounds 3 and 4 demonstrating stronger activity than the commonly used anti-inflammatory drug indomethacin at a concentration of 50 μM.
In situ architecture of a nucleoid-associated biomolecular co-condensate that regulates bacterial cell division.
Proc Natl Acad Sci U S A
January 2025
Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany.
In most bacteria, cell division depends on the tubulin-homolog FtsZ that polymerizes in a GTP-dependent manner to form the cytokinetic Z-ring at the future division site. Subsequently, the Z-ring recruits, directly or indirectly, all other proteins of the divisome complex that executes cytokinesis. A critical step in this process is the precise positioning of the Z-ring at the future division site.
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