The lethal effect of two x-ray doses can be considerably enhanced if cultured cells are exposed to actinomycin D between doses. Net survival can be modified by temperature as well as actinomycin treatment. These effects are related to repair of sublethal damage and to cell kinetics between doses.
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| http://dx.doi.org/10.1126/science.143.3613.1454 | DOI Listing |
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