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PLoS One
January 2025
Department of Pediatrics, Copenhagen University Hospital-North Zealand, Hillerød, Denmark.
Background: Identification of mother-infant pairs predisposed to early cessation of exclusive breastfeeding is important for delivering targeted support. Machine learning techniques enable development of transparent prediction models that enhance clinical applicability. We aimed to develop and validate two models to predict cessation of exclusive breastfeeding within one month among infants born after 35 weeks gestation using machine learning techniques.
View Article and Find Full Text PDFReprod Fertil Dev
January 2025
Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Context The adipose tissue produces adipokines - hormones essential to many biological functions, including reproduction. Aims We hypothesised that resistin, one of the adipokines, is present in the blood plasma, uterine luminal flushings (ULF) and uterus of pigs during the oestrous cycle and early pregnancy, and that resistin influences uterine steroidogenesis. Methods This study aimed to determine the expression of resistin in the porcine endometrium and myometrium during the cycle and pregnancy by quantitative real-time polymerase chain reaction and western blot (WB).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Background: CSF t-tau is considered a marker of neuronal injury in AD and strongly correlates with cognitive impairment. Evidence suggests that women accumulate more tau pathology early in AD than men. However, how pregnancy influences this relationship is unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Background: The Alzheimer's Disease Colombian kindred is the world's largest autosomal dominant cohort with Early Onset Familiar Alzheimer's Disease (EOAD) due to a single genetic variant. These families have been studied for decades, identifying the disease progression from early subclinical stages to late dementia stages. Such cognitive and functional decline impacts the mental and physical well-being of families and caregivers and to our knowledge, how being part of these families affects reproductive desire and contraception has not been studied.
View Article and Find Full Text PDFThe impact of diet-induced maternal obesity on offspring airway hyperresponsiveness was studied in a diversity outbred mouse model that mirrors human genetic diversity. Female mice were started on high-fat or regular diet 8 weeks before breeding and throughout pregnancy and lactation. After weaning, all offspring were fed a regular diet.
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