Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2337/diab.13.1.44 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Signalment, clinicopathological findings, management practices and comorbidities in cats with diabetes mellitus in Germany: cross-sectional study of 144 cases.
J Feline Med Surg
January 2025
Clinic for Small Animals (Internal Medicine, Clinical Pathology and Clinical Pathophysiology), Justus-Liebig-University Giessen, Germany.
Objectives: The aim of this study was to describe signalment, clinicopathological findings, management practices and the occurrence of comorbidities in feline diabetes mellitus (DM) in Germany.
Methods: This was a cross-sectional study using questionnaires and laboratory submissions to a commercial laboratory, Antech Lab Germany, between May 2021 and July 2022. Inclusion criteria were diagnosis of DM by the attending veterinarian and submission of a completed questionnaire besides blood samples.
Computational Approach to Elucidating Insulin-Protamine Binding Interactions and Dynamics in Insulin NPH Formulations.
ACS Omega
January 2024
Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
Insulin NPH is an intermediate-acting insulin. Its protracted action profile is due to the formation of microcrystalline suspensions when insulin is complexed with a basic peptide protamine, zinc ion, and phenolic ligands. Despite advancements in analytical techniques, the binding epitope and binding mode of the protamine in the insulin-protamine complex are still unknown.
View Article and Find Full Text PDFRefrigerated multi-dose insulin vials remain sterile through 6 months of use.
J Small Anim Pract
December 2023
North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
Objectives: To evaluate sterility in refrigerated multi-dose insulin vials through 6 months of routine aspiration.
Materials And Methods: Twelve vials of insulin, six of insulin glargine U100 (Lantus®, 10 mL multi-dose vial, Sanofi, Bridgewater, NJ) containing the preservative metacresol, and six of protamine zinc insulin U40 (ProZinc®, 10 mL multi-dose vial, Boehringer Ingelheim, Duluth, GA) containing the preservative phenol, were refrigerated and aspirated twice daily for 6 months, using a new insulin syringe each time. Three vials of each insulin type were wiped with a single-use alcohol swab before sampling.
One hundred years of insulin: Is it time for smart?
J Small Anim Pract
September 2022
Animal Diabetes Australia, Melbourne, Victoria, Australia.
Smarter understanding of diabetes pathophysiology and pharmacology of insulin therapy can lead to better clinical outcomes. Rather than looking for an insulin formulation that is considered "best" for a general population, it could be appropriate to seek the "smart" insulin choice, tailored to the specific clinical situation. Different treatment goals should be considered, with pros and cons to each.
View Article and Find Full Text PDFPharmacological Management of Diabetes Mellitus: A Century of Expert Opinions in Cecil Textbook of Medicine.
Am J Ther
June 2021
Department M3 Internal Medicine I "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Târgu Mure, Romania; and.
Background: Drug therapy for diabetes mellitus (DM) has had a significant impact on quality of life and work potential of affected persons and has contributed to a remarkable decrease in the frequency and severity of complications, hospitalizations, and mortality. The current approach is the result of incremental progress in using technological advances to increase the safety and effectiveness of insulin therapy and the introduction of new molecules as oral and injectable antidiabetic drugs.
Study Question: What are the milestones of the changes in the expert approach to the pharmacological management of DM in the past century?
Study Design: To determine the changes in the experts' approach to the management of DM, as presented in a widely used textbook in the United States.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!