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Revealing miRNAs' Janus-Faced Nature: Transforming Cold Tumours into Immunotherapy Hotspots and Overcoming Chemoresistance.
Microrna
January 2025
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, 20130, India.
MicroRNA (miRNA) modulation has emerged as a promising strategy in cancer immunotherapy, particularly in converting "cold" tumors with limited immune cell infiltration into "hot" tumors responsive to immunotherapy. miRNAs regulate immune cell recruitment and activation within the tumor microenvironment, influencing tumor behavior targeting specific miRNAs in cold tumors aims to enhance the immune response, potentially improving therapeutic efficacy. Despite ongoing research challenges, such as tumor complexity and treatment resistance, miRNA-based therapies offer personalized approaches with potential ethical considerations.
View Article and Find Full Text PDFKnowledge, Attitudes, Perceptions, and Practices Related to Artificial Intelligence in Radiology Among Indian Radiologists and Residents: A Multicenter Nationwide Study.
Cureus
December 2024
Community and Family Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Background Artificial Intelligence (AI) is revolutionizing medical science, with significant implications for radiology. Understanding the knowledge, attitudes, perspectives, and practices of medical professionals and residents related to AI's role in radiology is crucial for effective integration. Methods A cross-sectional survey was conducted among members of the Indian Radiology & Imaging Association (IRIA), targeting practicing radiologists and residents across academic and non-academic institutions.
View Article and Find Full Text PDFWorkload in the Austrian IT-sector regarding leadership roles.
Front Sociol
January 2025
Sigmund Freud University Vienna, Faculty of Psychotherapy Science, Vienna, Austria.
This paper investigates the impact of workload on leadership roles within the Austrian IT sector, by also paying attention to differences between genders. The research adopted a prospective design, selecting IT professionals, stratified by those with and without personnel responsibility and examined further through the lens of gender. A total of 200 participants completed the survey, where the modified German version of the Copenhagen Psychosocial Questionnaire (COPSOQ) served as the primary tool, which evaluated dimensions such as demands, influence, interpersonal relations, work interface, and conflicts.
View Article and Find Full Text PDFDomestic water consumptions and associated factors in rural household of Harari region, Eastern Ethiopia; A cross sectional study.
Front Public Health
January 2025
Department of Environmental Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Background: Sustainable rural water supply management requires accurate estimations of water consumption and understanding factors influencing consumption. Climate change exacerbates challenges, especially in developing countries with high poverty and limited access to clean water. Ethiopia has the lowest municipal water supply in Africa.
View Article and Find Full Text PDFTime Trends in Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention: Meta-Analysis on Sex Differences.
JACC Adv
February 2025
Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: Percutaneous coronary intervention (PCI) is considered the procedure of choice for patients with acute coronary syndrome (ACS), as it significantly improves cardiovascular outcomes. However, considerable uncertainty persists regarding the potential sex differences in PCI outcomes, due to conflicting results in previous studies.
Objectives: This meta-analysis aims to evaluate potential sex-related differences in cardiovascular adverse outcomes after PCI among ACS patients.
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