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Background And Aim: Phosphate dysregulation is often associated with chronic kidney disease (CKD), and recent studies suggest that it may also be present in non-CKD patients with systemic conditions including iron deficiency anemia. This study aimed to evaluate the relationship between iron deficiency parameters (total iron-binding capacity {TIBC}, hemoglobin, and serum ferritin) and markers of proximal tubular dysfunction (the maximal tubular reabsorption of phosphate normalized to glomerular filtration rate {TmP/GFR} and tubular reabsorption of phosphate {TRP}) in non-CKD patients with iron deficiency anemia.
Methods: This was a hospital-based analytical cross-sectional study conducted in the outpatient department and/or inpatient wards of the Department of Internal Medicine, Swaroop Rani Nehru (SRN) Hospital associated with Moti Lal Nehru (MLN) Medical College, Prayagraj, Uttar Pradesh, India, between July 2023 and August 2024.
Background: For patients with head and neck cancer who have undergone microvascular free flap surgery, securing a tracheostomy collar onto the neck using the traditional method (ie, with tracheostomy ties) is contraindicated because the ties may compress the newly vascularized tissue. However, no clear guidance exists for the use of other methods in these patients. Current techniques often use safety pins, which can cause injury to staff members.
View Article and Find Full Text PDFAdvancements in aspiration catheter tip design for thrombectomy: a comprehensive patent review.
Front Med Technol
November 2024
Department of BioMechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Delft, Netherlands.
Thrombus removal from the human body is facilitated through the utilization of aspiration catheters during minimally invasive thrombectomy procedures, where a pressure differential guides the targeted tissue through a flexible tubular medical instrument. In this paper, we present a patent analysis of thrombectomy aspiration catheter tip designs sourced from the EspaceNet database. Our findings reveal that enhancing the operability of aspiration catheters can be achieved by improving ease of positioning or suction capacity, whether through active or passive means.
View Article and Find Full Text PDFThermoforming for Small Feature Replication in Melt Electrowritten Membranes to Model Kidney Proximal Tubule.
Adv Healthc Mater
January 2025
Department of Pharmaceutical Sciences, Div. Pharmacology, Utrecht University, Utrecht, 13102, The Netherlands.
A novel approach merging melt electrowriting (MEW) with matched die thermoforming to achieve scaffolds with micron-sized curvatures (200 - 800 µm versus 1000 µm of mandrel printing) for in vitro modeling of the kidney proximal tubule (PT) is proposed. Recent advances in this field emphasize the relevance of accurately replicating the intricate tissue microenvironment, particularly the curvature of the nephrons' tubular segments. While MEW offers promising capabilities for fabricating highly and porous precise 3D structures mimicking the PT, challenges persist in approximating the diameter of tubular scaffolds to match the actual PT.
View Article and Find Full Text PDFHead-to-head comparison of F-sodium fluoride coronary PET imaging between a silicon photomultiplier with digital photon counting and conventional scanners.
J Nucl Cardiol
December 2024
Department of Medicine, Division of Artificial Intelligence in Medicine, Imaging, and Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:
Article Synopsis
- The study compared the effectiveness of silicone photomultipliers (SiPM) and traditional photomultiplier tubes (PMT) in PET imaging for coronary plaque activity using F-sodium fluoride (F-NaF).
- Conducted with 25 cardiovascular patients, the research measured image noise, signal-to-noise ratio (SNR), and target-to-background ratio (TBR) using both PET systems.
- Results demonstrated that SiPM PET provided clearer images with significantly lower noise levels and higher SNR and TBR compared to PMT PET, indicating better performance for coronary imaging.
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