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Analytical sensitivity factors from distributions of time of flight of photons for near-infrared spectroscopy studies in multilayered turbid media.
J Biomed Opt
January 2025
CIFICEN (UNCPBA - CICPBA - CONICET), Tandil, Argentina.
Significance: In the last years, time-resolved near-infrared spectroscopy (TD-NIRS) has gained increasing interest as a tool for studying tissue spectroscopy with commercial devices. Although it provides much more information than its continuous wave counterpart, accurate models interpreting the measured raw data in real time are still lacking.
Aim: We introduce an analytical model that can be integrated and used in TD-NIRS data processing software and toolkits in real time.
What Is the Clinical Value of Long Head of Biceps Tendon Tests in Distal Supraspinatus Tendon Rupture? A Prospective Multicenter Study.
J Shoulder Elbow Surg
January 2025
Université de Tours - Faculté de Médecine de Tours - CHRU Tours, Hôpital Trousseau, Service d'Orthopédie Traumatologie, Tours, France. Electronic address:
Purpose: The purpose of this study was to determine the clinical value of diagnostic tests for the long head of the biceps tendon (LHBT) injuries in the setting of a Patte stage 1 supraspinatus tendon rupture.
Methods: This was a prospective cohort multicenter study of 361 patients aged 30 to 80 years with Patte stage 1 distal supraspinatus tendon rupture. The LHBT was assessed clinically by palpation of the bicipital groove, the speed test, the Yergason test and the Kibler test.
The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery.
Inf inference
March 2025
Program in Applied Mathematics, Yale University, New Haven, CT 06520, US.
Detecting and recovering a low-rank signal in a noisy data matrix is a fundamental task in data analysis. Typically, this task is addressed by inspecting and manipulating the spectrum of the observed data, e.g.
View Article and Find Full Text PDFOn the directional asymptotic approach in optimization theory.
Math Program
July 2024
Department of Mathematics and Computer Science, Philipps-Universität Marburg, 35032 Marburg, Germany.
As a starting point of our research, we show that, for a fixed order , each local minimizer of a rather general nonsmooth optimization problem in Euclidean spaces is either M-stationary in the classical sense (corresponding to stationarity of order 1), satisfies stationarity conditions in terms of a coderivative construction of order , or is asymptotically stationary with respect to a critical direction as well as order in a certain sense. By ruling out the latter case with a constraint qualification not stronger than directional metric subregularity, we end up with new necessary optimality conditions comprising a mixture of limiting variational tools of orders 1 and . These abstract findings are carved out for the broad class of geometric constraints and , and visualized by examples from complementarity-constrained and nonlinear semidefinite optimization.
View Article and Find Full Text PDFIdentification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against c-Jun N-terminal kinase SMJNK.
Front Parasitol
April 2024
Institut für Parasitologie, Biomedizinisches Forschungszentrum Seltersberg (BFS), Justus Liebig Universitaet Giessen, Giessen, Germany.
Introduction: Schistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful level of selectivity, there is a compelling need to expand the chemical space available for synthesizing new, potent, and selective PK inhibitors. Small-molecule inhibitors targeting the ATP pocket of the catalytic domain of PKs have the potential to become drugs devoid of (major) side effects, particularly if they bind selectively.
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