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Protective role of hesperetin in Drosophila melanogaster model of ferrous sulphate-induced toxicity.
BMC Pharmacol Toxicol
September 2024
Molecular Drug Metabolism and Toxicology Unit, Department of Biochemistry, University of Ibadan, Ibadan, Oyo State, Nigeria.
The toxicological hazard of iron-containing products is a public health concern that inspires research in identifying and developing readily available, inexpensive antidotes. Natural products, like plant-sourced antioxidants, can be of great value in this regard. Hesperetin a flavonoid abundantly present in citrus fruits is known to possess a diverse pharmacological and antioxidant attribute.
View Article and Find Full Text PDFMitigation of drought stress in maize and sorghum by humic acid: differential growth and physiological responses.
BMC Plant Biol
June 2024
Botany Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Background: Drought is a major determinant for growth and productivity of all crops, including cereals, and the drought-induced detrimental effects are anticipated to jeopardize world food security under the ongoing global warming scenario. Biostimulants such as humic acid (HA) can improve drought tolerance in many cereals, including maize and sorghum. These two plant species are genetically related; however, maize is more susceptible to drought than sorghum.
View Article and Find Full Text PDFBoldine protects against carbon tetrachloride-induced chronic liver injury by regulating NF-κB signaling pathway.
J Biochem Mol Toxicol
April 2024
Department of Anatomy, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Sustained liver injuries predominantly promote oxidative stress and inflammation that lead to the progression of chronic liver disease (CLD), including fibrosis, cirrhosis, and hepatocellular carcinoma. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory effects. Currently, there is no definitive treatment option available for CLD.
View Article and Find Full Text PDFFruit softening: evidence for rhamnogalacturonan lyase action in vivo in ripe fruit cell walls.
Ann Bot
April 2024
The Edinburgh Cell Wall Group, Institute of Molecular Plant Sciences, The University of Edinburgh, Daniel Rutherford Building, The King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
Background And Aims: The softening of ripening fruit involves partial depolymerization of cell-wall pectin by three types of reaction: enzymic hydrolysis, enzymic elimination (lyase-catalysed) and non-enzymic oxidative scission. Two known lyase activities are pectate lyase and rhamnogalacturonan lyase (RGL), potentially causing mid-chain cleavage of homogalacturonan and rhamnogalacturonan-I (RG-I) domains of pectin respectively. However, the important biological question of whether RGL exhibits action in vivo had not been tested.
View Article and Find Full Text PDFAdvances in xanthine biosensors and sensors: A review.
Enzyme Microb Technol
March 2024
Department of Biochemistry, M.D. University, Rohtak, 124001 Haryana, India. Electronic address:
Xanthine is derived from hypoxanthine by xanthine oxidase (XOD), a flavoprotein containing molybdenum and non-haem iron, sulfur and from guanine by guanine deaminase enzyme. Xanthine is oxidized into uric acid by XOD. Xanthine is used as an indicator of fish freshness, based on the reactions in which ATP is degraded into xanthine and its quantity increases with time of fish death.
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