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Potentiating CD20 monoclonal antibody therapy by targeting complement C3 fragment covalently deposited on lymphoma cells.
Blood
January 2025
NIH, National Heart Lung Blood Institute, Bethesda, Maryland, United States.
Monoclonal antibodies (mAbs) improve survival of patients with mature B-cell malignancies. Fcγ-receptor dependent effector mechanisms kill tumor cells but can promote antigen loss through trogocytosis, contributing to treatment failures. Cell-bound mAbs trigger the complement cascade to deposit C3 activation fragments and lyse cells.
View Article and Find Full Text PDFInduction of Fc-dependent functional antibodies against different variants of SARS-CoV-2 varies by vaccine type and prior infection.
Commun Med (Lond)
December 2024
Burnet Institute, Melbourne, Australia.
Background: SARS-CoV-2 transmission and COVID-19 disease severity is influenced by immunity from natural infection and/or vaccination. Population-level immunity is complicated by the emergence of viral variants. Antibody Fc-dependent effector functions are as important mediators in immunity.
View Article and Find Full Text PDFPrinciples of Therapeutic Apheresis in Neurological Disease.
Transfus Med Hemother
April 2023
Division of Transfusion Medicine, Cell Therapeutics and Haemostaseology, University Hospital, LMU Munich, Munich, Germany.
Background: Therapeutic plasma exchange (TPE) is a well-known apheresis technology since many years and is available worldwide. Myasthenia gravis is one of the first neurological diseases successfully treated with TPE. TPE is also frequently applied in acute inflammatory demyelinating polyradiculoneuropathy (Guillain-Barré syndrome).
View Article and Find Full Text PDFPremature birth associated with a favorable course in gestational alloimmune liver disease (GALD): A case report.
Front Pediatr
March 2023
Department of Pediatrics, University of Erlangen-Nürnberg, Erlangen, Germany.
Gestational alloimmune liver disease (GALD) is a rare neonatal disorder with high mortality and morbidity. The patients come to caregivers' attention aged a few hours or days. The disease manifests as acute liver failure with or without siderosis.
View Article and Find Full Text PDFBroad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19.
Cell Rep Med
June 2021
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
The pathogenesis of severe coronavirus disease 2019 (COVID-19) remains poorly understood. While several studies suggest that immune dysregulation plays a central role, the key mediators of this process are yet to be defined. Here, we demonstrate that plasma from a high proportion (93%) of critically ill COVID-19 patients, but not healthy controls, contains broadly auto-reactive immunoglobulin M (IgM) and less frequently auto-reactive IgG or IgA.
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