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Gramicidin A in Asymmetric Lipid Membranes.
Biomolecules
December 2024
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31/4 Leninskiy Prospekt, 119071 Moscow, Russia.
Gramicidin A is a natural antimicrobial peptide produced by . Its transmembrane dimer is a cation-selective ion channel. The channel is characterized by the average lifetime of the conducting state and the monomer-dimer equilibrium constant.
View Article and Find Full Text PDFCPNE7 promotes colorectal tumorigenesis by interacting with NONO to initiate ZFP42 transcription.
Cell Death Dis
December 2024
Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death globally. Also, there is still a lack of effective therapeutic strategies for CRC patients owing to a poor understanding of its pathogenesis. Here, we analysed differentially expressed genes in CRC and identified CPNE7 as a novel driver of colorectal tumorigenesis.
View Article and Find Full Text PDFTime-resolved electromechanical and conductive behavior of nanostructured bilayers tethered to the surface of the electrode with incorporated channel proteins and peptides.
Bioelectrochemistry
April 2025
Faculty of Chemistry, University of Warsaw, 1 Pasteur Street, 02-093 Warsaw, Poland. Electronic address:
Article Synopsis
- The study explores how mitochondrial potassium channels and the peptide Gramicidin affect ion transport and electrical properties in lipid membranes attached to gold electrodes.
- Techniques like chronoamperometry and impedance spectroscopy were used to analyze how the potassium channel's transport abilities can be altered using the ATP-Mg complex inhibitor, and how Gramicidin's function changes when sodium replaces potassium.
- The findings show two different current-time responses, which reflect ion movement and changes in the lipid membrane, and were further validated through experiments with self-assembled monolayers on gold surfaces.
Evaluating the impact of the membrane thickness on the function of the intramembrane protease GlpG.
Biophys J
December 2024
Institute for Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany. Electronic address:
Cellular membranes exhibit a huge diversity of lipids and membrane proteins that differ in their properties and chemical structure. Cells organize these molecules into distinct membrane compartments characterized by specific lipid profiles and hydrophobic thicknesses of the respective domains. If a hydrophobic mismatch occurs between a membrane protein and the surrounding lipids, there can be functional consequences such as reduced protein activity.
View Article and Find Full Text PDFThe Termite Nest-Associated Bacterium Brevibacillus parabrevis WGTm-23 Contains Unique Biosynthetic Gene Clusters Potentially Coding for Novel Antimicrobial Agents.
Curr Microbiol
September 2024
Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, India.
Multidrug resistance in clinical pathogens is a significant challenge in healthcare, requiring the development of novel approaches to combat infections. In this study, we report the identification of novel antimicrobial biosynthetic gene clusters from Brevibacillus parabrevis WGTm-23, the bacterial strain isolated from a termitarium. This strain showed an antagonistic effect against drug-resistant clinical pathogens, such as Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella paratyphi, Streptococcus gordonii, and enteropathogenic Escherichia coli.
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