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Clinical utility of the lymphocyte proliferation assay, an in vitro functional readout of the adaptive immune response.
J Immunol Methods
January 2025
ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:
Despite great advancements in the discovery of genetic variants underlying inborn errors of immunity, functional assessment of the immunological profile of patients in routine clinical practice remains challenging. The lymphocyte proliferation assay using H-thymidine incorporation has been the gold standard for decades for functional evaluation of T cells in the clinical laboratory, however, recently developed flow cytometry methods allowing for single cell analysis provide non-radioactive alternatives. Understanding the technical and analytical challenges of test development, validation and maintenance is essential for correct interpretation and test utilization, to assure appropriate and timely patient care.
View Article and Find Full Text PDFFrom collective to individual radon risk exposure: An insight into the current European regulation.
Environ Int
January 2025
Dipartimento di Geoscienze, Università di Padova, Padova, Italy.
Radon (Rn) is a radioactive gas with well-documented harmful effects; the World Health Organization has confirmed it as a cancerogenic for humans. These detrimental effects have prompted Europe to establish national reference levels to protect the exposed population. This is reflected in European directive 59/2013/EURATOM, which has been transposed into the national regulations of EU Member States.
View Article and Find Full Text PDFRevisiting the historical tritium levels in precipitation in Greece - Preliminary assessment of groundwater transit times.
J Environ Radioact
January 2025
International Atomic Energy Agency, Isotope Hydrology Section, Vienna International Centre, Vienna, Austria.
The radioactive isotope of hydrogen, known as tritium (H), is very often used as a dating tool in hydrogeological studies, since it enters the water cycle as part of the water molecule through precipitation. However, the assessment of groundwater transit times and recharge often requires knowing the local historical records of tritium levels in precipitation during the previous seven decades, or the tritium in precipitation (TIP) time series. Here, we compiled all tritium records in precipitation in Greece, with the majority of stations showing sporadic measurements, with the aim of reconstructing a TIP for groundwater dating purposes.
View Article and Find Full Text PDFDispersion behavior of Fukushima-derived Cs over the North Pacific with emphasis on its sensitivity to vertical velocity and diffusion.
Mar Pollut Bull
January 2025
Ocean Environment Institute, Oceanic Consulting and Trading, Seoul, Republic of Korea.
This study simulated the dispersion of Cs in the North Pacific using a Lagrangian particle model, incorporating basin-wide atmospheric deposition and direct release from the Fukushima accident. Three experiments examined the impact of vertical diffusion and velocity on dispersion behavior. EXP01 and EXP02 assumed zero vertical velocity with different vertical diffusion coefficients (1 × 10 and 2 × 10 m/s, respectively), while EXP03 used a 3-day average vertical velocity and the same diffusion coefficient as EXP01.
View Article and Find Full Text PDFEco-friendly synthesis of rod-like hydroxyapatite on spherical carbon: A dual-function composite for selective cobalt removal and enhanced oxygen evolution reaction.
J Hazard Mater
January 2025
Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 04620, Republic of Korea. Electronic address:
The presence of cobalt ions (Co) and radionuclides (Co) in industrial and radioactive effluents pose serious threats to environmental ecosystems and human health. This paper presents the synthesis of dual-functional hydroxyapatite (HAp)-incorporated spherical carbon (SC) composite (HAp/SC) towards the selective adsorption of cobalt from wastewater and the utilization of the Co-adsorbed HAp/SC composite (Co- HAp/SC) as an electrocatalyst for the oxygen evolution reaction (OER). Herein, we prepared a series of HAp/SC composites by varying HAp weight percentages of 10 %, 20 %, 30 %, 40 %, and 50 %.
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