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Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.
Brief Bioinform
November 2024
Department of Dermatology, Daping Hospital, Army Medical University, No. 10, Changjiang Branch Road, Yuzhong District, Chongqing 400042, China.
Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy psychological and physical burden. The existing therapeutic schemes have many deficiencies such as limited efficacies and various side effects. Therefore, novel ways of treating psoriasis are urgently needed.
View Article and Find Full Text PDFGenetic Diversity and Prevalence of Blastocystis Subtypes in Alborz Province, Iran: A Molecular Epidemiological Study.
Acta Trop
January 2025
Associate Professor, Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.
The primary objective of this study was to evaluate the genetic diversity of Blastocystis. Additionally, it aimed to explore, for the first time in Iran, the potential association between Blastocystis infection and ABO blood groups. Another focus was to examine the relationship between Blastocystis subtypes and blood groups, an often overlooked risk factor, within the population of Alborz Province, Iran.
View Article and Find Full Text PDFColor doppler blood flow analysis in circumscribed choroidal hemangioma.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology & Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: To evaluate if color Doppler can detect internal blood flow in circumscribed choroidal hemangioma.
Methods: This cross-sectional study examined seven eyes of seven participants with circumscribed choroidal hemangiomas, with or without prior treatment. B-scan ultrasound and color Doppler were used to assess the dimensions, topographical distribution, and internal blood flow of the affected eyes.
Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer.
Sci Rep
January 2025
Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and the risk of gastric cancer using a two-sample Mendelian randomization approach. We utilized genome-wide association study (GWAS) data to perform two-sample Mendelian randomization analyses, treating the 4,907 plasma proteins as exposure factors and gastric cancer as the outcome. Instrumental variables for plasma proteins were selected based on strongly correlated SNPs identified through data processing and screening of the GWAS data provided by the deCode database.
View Article and Find Full Text PDFCryofibrinogenemia as a cause of ABO forward/reverse discrepancy and positive antibody screen result.
Transfusion
January 2025
Department of Pathology and Laboratory Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.
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