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The diagnostic value of metagenomic next-generation sequencing in critically ill patients with sepsis: A retrospective cohort study.
Medicine (Baltimore)
October 2024
Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Article Synopsis
- mNGS is a promising high-throughput sequencing method for diagnosing sepsis, showing potential benefits in early detection and clinical management.
- The study analyzed 150 sepsis patients from multiple hospitals, comparing mNGS to traditional microbiological tests (CMT) to assess its diagnostic effectiveness.
- Results indicated that mNGS had high sensitivity (84.4%) for identifying infections, particularly for viral and fungal pathogens, but with moderate overall accuracy (56.0%), suggesting it could be a valuable tool for managing critically ill patients.
Prevalence of Respiratory Pathogens in Nasopharyngeal Swabs of Febrile Patients with or without Respiratory Symptoms in the Niakhar Area of Rural Senegal.
Pathogens
August 2024
Campus Santé Timone, Aix Marseille University, AP-HM, SSA, RITMES, 13005 Marseille, France.
Article Synopsis
- Acute respiratory infections are a major global health issue, and more research is needed on the microorganisms causing these infections in various regions, particularly in Senegal.
- In a study of 500 febrile patients, researchers found that 73.2% had at least one detectable microorganism, with viruses and bacteria commonly identified, including influenza and RSV.
- The presence of certain microorganisms was linked to respiratory symptoms, and co-infections were also associated with more severe symptoms, highlighting the need for better diagnostic tools to adapt treatment strategies.
An exploration of blood-based biomarkers of negative symptoms of psychosis in men.
J Psychiatr Res
September 2024
Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address:
Negative symptoms in the context of psychosis are still poorly understood and diagnosed, which impairs the treatment efficacy of current therapies and patient's integration in society. In this study, we aimed to test hypothesis-based and exploratory associations of negative symptom domains, as defined by the Brief Negative Symptom Scale (BNSS), with hormonal and hematological variables, and, complementarily, with standard psychological/cognitive and psychopathological measures. Fifty-one male patients diagnosed with a psychotic disorder underwent a structured interview and blood collection.
View Article and Find Full Text PDFThe etiological diagnostic value of metagenomic next-generation sequencing in suspected community-acquired pneumonia.
BMC Infect Dis
June 2024
Department of Pulmonary and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Article Synopsis
- The study investigates the effectiveness of metagenomic next-generation sequencing (mNGS) for diagnosing pathogens in community-acquired pneumonia (CAP) by analyzing 555 bronchoalveolar lavage fluid samples from 541 patients.
- Results show that mNGS has a significantly higher positivity rate (79.1%) compared to sputum culture (11.4%), highlighting its potential for better pathogen detection.
- While mNGS is effective for identifying various pathogens, it is less sensitive for detecting active tuberculosis compared to the X-pert MTB/RIF test (64.6% vs. 85.4%).
Etiological diagnostic performance of probe capture-based targeted next-generation sequencing in bloodstream infection.
J Thorac Dis
April 2024
Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: A rapid and precise etiological diagnosis is crucial for the effective treatment of bloodstream infection (BSI). In this study, the performance of probe capture-based targeted next-generation sequencing (tNGS) was compared to that of blood culture and metagenomic next-generation sequencing (mNGS) in detecting potential pathogens in patients with BSI.
Methods: A total of 80 patients with suspected BSI were prospectively enrolled from 24 November 2023 to 30 December 2023 at Zhongshan Hospital, Shanghai, China.
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