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C3 Glomerulonephritis Associated with Monoclonal Gammopathy.
Indian J Nephrol
June 2024
Department of Nephrology, Setubal Hospital Center, Setúbal, Portugal.
C3 glomerulonephritis (C3GN) is rare. It is a proliferative glomerulonephritis resulting from glomerular deposition of complement factors due to dysregulation of the alternative pathway of complement. The association between monoclonal protein production and development of C3GN was described.
View Article and Find Full Text PDFÖrjan Ouchterlony and the antigen-antibody double diffusion-in-gel: a survey.
APMIS
January 2025
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
The Swedish scientist Örjan Ouchterlony published four ground-breaking papers 1948-1966 in Acta Pathol Microbiol Scand where he described a new method of antigen-antibody reactions in gel. He described and defined the 'reaction of identity' and 'reaction of partial identity' when he used related antigens and 'reaction of non-identity' when he used non-related antigens. His results inspired scientists in other countries to further develop and modify the 'Ouchterlony method' which became useful for both scientific and clinical purposes.
View Article and Find Full Text PDFBackground: We examined the physicochemical properties of IgD-type M protein from 10 patients with IgD-type M protein and those with other types of M protein.
Methods: Identification of the L-chain type by routine methods (Immunoelectrophoresis: IEP, Immunofixation electrophoresis; IFE), detection of IgD-IgG complexes and the changes in the mobility by treatment with acid.
Results: Identification of the L-chain type by both IEP and IFE was impossible.
Common Bean Suppresses Hepatic Ceramide Metabolism in a Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease.
Nutrients
September 2024
Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA.
The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), a condition linked to the ongoing obesity pandemic, is rapidly increasing worldwide. In turn, its multifactorial etiology is consistently associated with low dietary quality. Changing dietary macronutrient and phytochemical quality via incorporating cooked common bean into an obesogenic diet formulation has measurable health benefits on the occurrence of both obesity and hepatic steatosis in C57BL/6 mice.
View Article and Find Full Text PDFImpact of M-protein detection on the response evaluations of patients undergoing treatment with the IgG-κ monoclonal antibodies daratumumab or isatuximab, and discrepancies between immunofixation electrophoresis (IFE) systems and reagents.
Cancer Med
August 2024
Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Background: Immunofixation electrophoresis (IFE) is the standard method for confirming the presence of a monoclonal protein (M-protein) at multiple myeloma (MM) diagnosis. IFE is also essential at assessment of complete response (CR) and stringent CR during treatment. As the CR assessment is influenced by daratumumab and isatuximab, HYDRASHIFT assays were developed.
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