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How a medical mystery led to a cure for viral hepatitis.
Nat Med
January 2025
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Metabolite mysteries: Decoding age-related muscle fatigue mechanisms at the myofibrillar level.
J Physiol
January 2025
Muscle Health Research Centre, School of Kinesiology & Health Science, Faculty of Health, York University, Toronto, ON, Canada.
Unraveling the mystery: effect of trapped air on platelet adhesion on hydrophobic nanostructured titanium dioxide.
Biomater Sci
January 2025
Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, College of Physical Science and Technology, Xiamen University, Xiamen 361005, China.
Nature-inspired superhydrophobic materials have attracted considerable interest in blood-contacting biomedical applications due to their remarkable water-repellent and self-cleaning properties. However, the interaction mechanism between blood components and superhydrophobic surfaces remains unclear. To explore the effect of trapped air on platelet adhesion, we designed four distinct hydrophobic titanium dioxide (TiO) nanostructures with different fractions of trapped air.
View Article and Find Full Text PDFMy beloved husband, Robert Steel, died at 58 from MAPT FTD, a disease that stretches back through his family's generations. Before we married he told me his father died of early-onset Alzheimers and he was terrified he would inherit that disease. In his early 50s he began exhihibiting symptoms that I attributed to stress-his work as a respected high school teacher began to slip, he began to lose the ability to have a visual map in his head, he began to repeat stories, his behavior became more compulsive, forgot how he was related to a favorite cousin.
View Article and Find Full Text PDFMonte Carlo in the mechanistic modelling of the FLASH effect: a review.
Phys Med Biol
January 2025
Physics, The University of Western Australia, 35 Stirling Highway, Mailbag M013, WA 6009, Perth, 6009, AUSTRALIA.
FLASH radiotherapy employs ultra-high dose rates of >40 Gy/s, which may reduce normal tissue complication as compared to conventional dose rate treatments, while still ensuring the same level of tumour control. The potential benefit this can offer to patients has been the cause of great interest within the radiation oncology community, but this has not translated to a direct understanding of the FLASH effect. The oxygen depletion and inter-track interaction hypotheses are currently the leading explanations as to the mechanisms behind FLASH, but these are still not well understood, with many questions remaining about the exact underpinnings of FLASH and the treatment parameters required to optimally induce it.
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