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Objective: To study the timing of the effect of linzagolix, an oral GnRH antagonist, on significant reduction in heavy menstrual bleeding (HMB) in women with uterine fibroids.
Design: The study used pooled data from PRIMROSE1 and PRIMROSE2, two double-blind, similar placebo-controlled trials of linzagolix in US and Europe, respectively. Eligible participants were randomized equally across four treatment arms (linzagolix 100mg and 200mg, with and without concomitant hormonal add-back therapy [ABT] consisting of 1 mg estradiol and 0.
Assessing Practice Patterns Regarding Use of Norethindrone Acetate in Adolescents.
J Pediatr Adolesc Gynecol
December 2024
Division of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis.
Background: Norethindrone acetate (NETA) is commonly used in adolescent patients for management of heavy menstrual bleeding, menstrual suppression, and endometriosis. Clinical guidelines do not address specific dosing strategies, clinical indications, contraindications, or monitoring. We sought to survey current prescribers of NETA to assess practice patterns of use among adolescent patients.
View Article and Find Full Text PDFA Comparative Metabolomics Study of the Potential Marker Compounds in Feces from Different Hybrid Offspring of Huainan Pigs.
Animals (Basel)
November 2024
Henan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Henan Pig Breeding Engineering Research Centre, Institute of Animal Husbandry, Henan Academy of Agricultural Sciences, Number 116, Hua Yuan Road, Jinshui District, Zhengzhou 450002, China.
As a notable native Chinese genetic population, the Huainan pig has an exceptional meat quality but a low percentage of lean meat and subpar genetic performance. To better exploit the superior genetic traits of the Huainan pig and address knowledge gaps regarding the optimization of its hybrid offspring, this study used Huainan pigs as the maternal line and bred them with Yorkshire, Landrace, and Berkshire sires. This approach produced three hybrid combinations: Yorkshire × Huainan (YH), Landrace × Huainan (LH), and Berkshire × Huainan (BH).
View Article and Find Full Text PDFNET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.
Front Immunol
November 2024
McMaster Immunology Research Centre, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Depot-medroxyprogesterone acetate (DMPA) and Norethisterone Enanthate (NET-EN) are progestin-only injectable contraceptives widely used by women in sub-Sharan Africa, where incidence of HIV-1 and HSV-2 infection remains high. Studies indicate that DMPA usage can increase the risk of HSV-2 infection, but limited data indicate no increased risk with use of NET-EN. We therefore investigated the effects of NET-EN and DMPA on susceptibility to vaginal HSV-2 infection in ovariectomized (OVX) mice and effects on immune responses, particularly in the vaginal tract (VT).
View Article and Find Full Text PDFArticle Synopsis
- - The Progesterone Breast Endometrial Safety Study aims to compare the safety of micronised progesterone (mP) to synthetic progestins (norethisterone acetate) in hormone therapy for menopausal women, focusing on breast and endometrial health.
- - Conducted at three university hospitals in Sweden, the study consists of two parts: the first assesses breast safety in a double-blind trial with 260 women, while the second evaluates endometrial safety with an additional 260 women using mP.
- - The research has ethical approval and results will be shared in scientific publications and meetings, with a total of 520 participants in both phases combined.
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