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Dual-template epitope imprinted nanoparticles for anti-glycolytic tumor-targeted treatment.
J Colloid Interface Sci
December 2024
State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China; National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address:
Glycolysis provides tumors with abundant nutrients through glucose (Glu) metabolism. As a therapeutic target, precise targeting and effective inhibition of the glycolysis process remains a major challenge in anti-metabolic therapy. In this study, a novel dual-template molecularly imprinted polymer (D-MIP), capable of specifically recognizing glucose transporter member 1 (GLUT1) and hexokinase-2 (HK2) was prepared for anti-glycolytic tumor therapy.
View Article and Find Full Text PDFRice-Fish Farming Improved Antioxidant Defences, Glucose Metabolism, and Muscle Nutrient of in Sichuan Province.
Metabolites
December 2024
Fisheries Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu 611730, China.
Rice-fish farming is an ancient and enduring aquaculture model in China. This study aimed to assess the variations in digestive enzymes, antioxidant properties, glucose metabolism, and nutritional content between reared in paddy fields and ponds. Notably, the levels of amylase and trypsin in from rice paddies were considerably higher compared to those from ponds.
View Article and Find Full Text PDFOral exposure to ovalbumin alters glucose metabolism in sensitized mice: upregulation of HIF-1α-mediated glycolysis.
Food Funct
December 2024
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, Jiangxi, PR China.
Food allergies are pathological adverse reactions against harmless dietary proteins. While studies have shown the involvement of host metabolic changes (, lipid metabolism and amino acid metabolism) in the development of food allergy (FA), the adaptive changes in glucose metabolism induced by food allergen exposure remain largely unclear. In this study, BALB/c mice were sensitized intraperitoneally with an ovalbumin (OVA)/aluminum adjuvant, followed by oral OVA challenges to induce anaphylaxis.
View Article and Find Full Text PDFKDM4 Regulates the Glycolysis of Hemocytes in the Immune Priming of .
Int J Mol Sci
December 2024
College of Life Sciences, Liaoning Normal University, Dalian 116029, China.
Immune priming confers a sustained, augmented response of innate immune cells to a secondary challenge, a process that is characteristically reliant on metabolic reprogramming. Recent evidence suggests that histone demethylases play essential roles in the immune priming, while its regulation role in the metabolic reprogramming remains largely unknown. In the present study, the concentration of glucose was significantly down-regulated in the hemocytes of crab after secondary stimulation with , while the expression levels of phosphofructokinase (PFK) pyruvate kinase (PK), hexokinase-2 (HK-2) and Glucose-6-phosphate dehydrogenase (G-6-PD), along with the concentrations of lactate and the ratio of NAD/NADH, were elevated.
View Article and Find Full Text PDFInfluence of Alkaline Reduced Water Supplementation on Glucose and Lipid Metabolism in Non-Diabetic and Diabetic Rats.
Nutrients
November 2024
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan.
Background: With the global increase in metabolic disorders, identifying effective dietary strategies is crucial for enhancing health outcomes. While various health advantages of alkaline reduced water (ARW) have been documented, its specific impacts on glucose and lipid metabolism in both healthy and diabetic conditions are still not well understood.
Methods: This study investigates how ARW affects carbohydrate and lipid metabolism in male Wistar rats, which were induced to develop glucose metabolism disorders through subcutaneous injections of nicotinamide and streptozotocin (STZ).
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