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Evaluation of three rapigen biocredit point-of-care tests for malaria case management in Lagos, Nigeria.
J Infect Dev Ctries
November 2024
Aventis Pharmacy Ltd, Lokogoma, Abuja, Nigeria.
Introduction: Histidine-rich protein 2 (HRP2) antigen kits are widely used for malaria diagnosis in tropical regions due to their heat stability. The Plasmodium Lactate Dehydrogenase (pLDH) used in BIOCREDIT® malaria test kit is claimed to be heat-stable. This study aimed to evaluate the heat stability and field performance of three BIOCREDIT® kits.
View Article and Find Full Text PDFHeat-Stable Insulins: Any Progress?
J Diabetes Sci Technol
December 2024
Science Consulting in Diabetes GmbH, Düsseldorf, Germany.
Millions of people with diabetes have no or only limited access to electricity that limits their ability to store insulin according to the recommendations of the insulin manufacturer in general. At the same time, environmental temperatures are increasing in many countries which have a negative impact on the glucose-lowering effect of insulin not stored adequately. Therefore, the availability of heat-stable insulin formulations that do not require constant cooling would be of help for many patients; however, despite this clinical need, apparently not many are in clinical development.
View Article and Find Full Text PDFPostpartum Hemorrhage in Humanitarian Settings: Implementation Insights from Using Heat-Stable Carbetocin and Tranexamic Acid.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- Maternal mortality due to postpartum hemorrhage (PPH) is a significant issue in low-resource settings, and this study examines healthcare providers' perspectives on the effectiveness and challenges of using heat-stable carbetocin (HSC) and tranexamic acid (TXA) for prevention and treatment of PPH.
- The research involved semi-structured interviews and focus group discussions with 64 healthcare workers in South Sudan and Uganda, focusing on a PPH intervention package that included training, readiness kits, and a community support platform.
- Results indicated providers view HSC favorably for preventing bleeding and recognize TXA as effective but noted limited experience with it; challenges included medication confusion and record-keeping issues, while
Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in Uganda.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- - The study investigates the effectiveness of a capacity-strengthening package to promote the use of heat-stable carbetocin (HSC) and tranexamic acid (TXA) in preventing and treating postpartum hemorrhage (PPH) in basic obstetric clinics in Uganda during crisis situations.
- - A total of 2,299 women participated over a year, showing that while the use of prophylactic uterotonics was high, the introduction of HSC contributed to changes in the overall treatment practices, with a notable increase in TXA usage.
- - The results highlight that enhancing healthcare provider capabilities can lead to improved management of PPH, suggesting critical implications for global health strategies in humanitarian settings.
Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in South Sudan.
Int J MCH AIDS
September 2024
United Nations Population Fund, Humanitarian Response Division, Switzerland.
Article Synopsis
- The study assesses the impact of a capacity-strengthening package on the use of medications for preventing and treating postpartum hemorrhage (PPH) in South Sudan's basic maternity facilities.
- The implementation involved a series of phases introducing therapeutic protocols, including training and resources, resulting in improved use of uterotonics and a notable increase in PPH diagnoses.
- Findings indicate a transition in medication usage patterns, with oxytocin usage decreasing as heat-stable carbetocin and tranexamic acid were introduced, highlighting the need for effective PPH management strategies in crisis-affected areas.
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