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Preparation and validation of nanomolar aqueous bilirubin standard solutions.
MethodsX
June 2025
Department of Life Sciences, University of Trieste, Italy.
Bilirubin (BR) is the product of cellular heme catabolism and the main bile pigment in animal blood. It is an established biomarker for hemolysis and liver function. Over the last decade, mild hyperbilirubinemia has been shown to be a biomarker for a lower risk of cardiovascular disease, due to its antioxidant and anti-inflammatory effects.
View Article and Find Full Text PDFTherapeutic efficacy of against phenylhydrazine-induced hemolytic anemia in rats.
J Tradit Complement Med
January 2025
School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, India.
Background & Aim: Hemolytic anemia is a blood disorder whose incidence is increasing in the world in recent years especially after the pandemic. Conventional treatments include use of steroids and immunosuppresants that are accompanied by numerous adverse effects. With growing interest in using complex multi-component formulations for multi-targeted therapy, the present study aims to investigate the therapeutic efficacy of a traditional herbomineral preparation, , which has been traditionally used as a supplement in iron-deficiency anemia, against phenylhydrazine-induced hemolytic anemia in rodent models.
View Article and Find Full Text PDFTransarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study.
Lancet
January 2025
Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. Electronic address:
Article Synopsis
- TACE is the standard treatment for patients with unresectable, non-metastatic hepatocellular carcinoma, and this study evaluates the effectiveness of adding lenvatinib and pembrolizumab to TACE compared to a placebo.
- The multicenter, randomised, double-blind phase 3 study (LEAP-012) involved participants from 137 sites across 33 countries who were randomly assigned to receive either TACE with the new drugs or TACE with a placebo.
- The primary endpoints were progression-free survival and overall survival, and the results reported are from the first interim analysis, which serves as the final analysis for progression-free survival.
A biofuel cell of (methyl violet/AuNPs)/FTO photoanode and bilirubin oxidase/CuCoO bio-photocathode inspired by the photoelectrochemistry activities of fluorescent materials/molecules.
RSC Adv
January 2025
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University Changsha 410081 China
Herein, we discuss the idea that fluorescent materials/molecules should logically show potential photoelectrochemistry (PEC) activity, and, in particular, the PEC of fluorescent small molecules (previously usually acting only as dye sensitizers for conventional semiconductors) is explored. After examining the PEC activities of some typical inorganic or organic fluorescent materials/molecules and by adopting methyl violet (MV) with the highest PEC activity among the examined fluorescent small molecules, a new and efficient (MV/Au nanoparticles (AuNPs))/fluorine-doped tin oxide (FTO) photoanode without conventional semiconductor(s) is prepared by layer-by-layer alternating the electrodeposition of AuNPs and the adsorption of MV. A bilirubin oxidase (BOD)/CuCoO/FTO bio-photocathode is prepared by electrodeposition, calcination and cast-coating.
View Article and Find Full Text PDFDeep-Learning Model for Mortality Prediction of ICU Patients with Paralytic Ileus.
Bioengineering (Basel)
November 2024
Department of Mechanical and Industrial Engineering, University of Illinois Chicago, 942 W Taylor St., Chicago, IL 60607, USA.
Paralytic Ileus (PI) patients in the Intensive Care Unit (ICU) face a significant risk of death. Current predictive models for PI are often complex and rely on many variables, resulting in unreliable outcomes for such a serious health condition. Predicting mortality in ICU patients with PI is particularly challenging due to the vast amount of data and numerous features involved.
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