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Against the Current: Wilder Penfield, the Frontal Lobes and Psychosurgery.
Can J Neurol Sci
September 2019
Department of Neurology and Neurosurgery, Montreal Neurological Institute and McGill University, Montreal, Canada.
Psychosurgery refers to the surgical interruption of the white matter fibres joining the frontal cortex to the remainder of the cortical mantle and to the thalamus, in an attempt to mitigate the manifestations of psychosis. It reached its heyday following World War Two and was abandoned with the introduction of major tranquilisers such as chlorpromazine. Wilder Penfield, unlike most of his contemporaries, had a jaundiced view of psychosurgery.
View Article and Find Full Text PDFExperiments conducted on rabbits confirmed that chlorpromazine potentiates the weak epileptogenic action of Amipaque (metrizamide). Chlorpromazine withdrawal for a period of 48 h suppresses this potentiating effect in the rabbit. Neuroleptic drugs should therefore be avoided in patients examined with Amipaque.
View Article and Find Full Text PDFEffect of catecholaminergic drugs on epileptogenic properties of the caudate nucleus.
Neurosci Behav Physiol
August 1977
Drugs stimulating catecholaminergic transmission (dopa, apomorphine, amphetamine, and their combination with disulfiram) weakened the epileptogenic properties of the caudate nucleus in freely moving rats. Under the influence of these drugs the cortical electroencephalographic response to single stimulation of the nucleus was shortened in animals receiving subconbulsant doses of leptazol and the intensity of the spike-wave rhythm bound with repeated caudate stimuli was reduced. Conversely, inhibitors of catecholaminergic transmission (chlorpromazine, haloperidol, alpha-methyltyrosine, and disulfiram) potentiated the epileptogenic effects of the caudate nucleus.
View Article and Find Full Text PDFExperimental studies on facilitative and inhibitory factors for epileptogenic focus formation.
Folia Psychiatr Neurol Jpn
October 1974
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