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Pharmacological treatments in panic disorder in adults: a network meta-analysis.
Cochrane Database Syst Rev
November 2023
Newcastle upon Tyne, UK.
Background: A panic attack is a discrete period of fear or anxiety that has a rapid onset and reaches a peak within 10 minutes. The main symptoms involve bodily systems, such as racing heart, chest pain, sweating, shaking, dizziness, flushing, churning stomach, faintness and breathlessness. Other recognised panic attack symptoms involve fearful cognitions, such as the fear of collapse, going mad or dying, and derealisation (the sensation that the world is unreal).
View Article and Find Full Text PDFTherapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders.
CNS Neurol Disord Drug Targets
June 2024
Department of Pharmaceutics, SGT College of Pharmacy, SGT University, Gurugram, Haryana 122505, India.
Myricetin (MC), 3,5,7,3',4',5'-hexahydroxyflavone, chemically belongs to a flavonoid category known to confer antioxidant, antimicrobial, antidiabetic, and neuroprotective effects. MC is known to suppress the generation of Reactive Oxygen Species (ROS), lipid peroxidation (MDA), and inflammatory markers. It has been reported to improve insulin function in the human brain and periphery.
View Article and Find Full Text PDFNeuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action.
Antioxidants (Basel)
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Independent Researcher, 37128 Verona, Italy.
Neurological and neurodegenerative diseases, particularly those related to aging, are on the rise, but drug therapies are rarely curative. Functional disorders and the organic degeneration of nervous tissue often have complex causes, in which phenomena of oxidative stress, inflammation and cytotoxicity are intertwined. For these reasons, the search for natural substances that can slow down or counteract these pathologies has increased rapidly over the last two decades.
View Article and Find Full Text PDFClinical Application and Synthesis Methods of Deuterated Drugs.
Curr Med Chem
June 2023
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
Many drugs have adverse absorption, distribution, metabolism, and excretory (ADME) properties that prevent their widespread use or limit their use in some indications. In addition to preparation techniques and prodrug strategies, deuterium modification is a viable method for improving ADME properties. Deuterated drugs have attracted increasing attention from the pharmaceutical industry in recent years.
View Article and Find Full Text PDFChromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions.
Mini Rev Med Chem
September 2022
Department of Pharmaceutical Sciences, Faculty of Medical Science and Health, Gurukula Kangri University, Haridwar-249404, India.
Chromenes are an important class of oxygen-containing heterocyclic compounds with intriguing biological activity, a simple structure with mild adverse effects. Chromenes are abundantly found in nature in the form of alkaloids, tocopherols, flavone, and anthocyanins. The Chromene nucleus is an important moiety for the discovery of new drug candidates.
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