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| http://dx.doi.org/10.1128/jb.86.6.1346-1347.1963 | DOI Listing |
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Clinical Snapshot of Group A Streptococcal Isolates from an Australian Tertiary Hospital.
Pathogens
November 2024
Australian Infectious Diseases Research Centre, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4067, Australia.
(Group A , GAS) is a human-restricted pathogen that causes a wide range of diseases from pharyngitis and scarlet fever to more severe, invasive infections such as necrotising fasciitis and streptococcal toxic shock syndrome. There has been a global increase in both scarlet fever and invasive infections during the COVID-19 post-pandemic period. The aim of this study was the molecular characterisation of 17 invasive and non-invasive clinical non-1 GAS isolates from an Australian tertiary hospital collected between 2021 and 2022.
View Article and Find Full Text PDFRole of the SaeRS Two-Component Regulatory System in Group B Biofilm Formation on Human Fibrinogen.
Microorganisms
October 2024
Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", University of Messina, 98168 Messina, Italy.
Article Synopsis
- Group B Streptococcus (GBS) is a common bacterium that can become harmful to newborns, pregnant women, and the elderly, and its biofilm formation is crucial for its pathogenicity.
- Researchers created a model to study GBS biofilm formation using human fibrinogen (hFg), finding that this leads to a robust biofilm structure supported by proteins and extracellular DNA (eDNA).
- The study revealed that the SaeRS regulatory system is essential for biofilm development, with its absence significantly hindering biomass and disrupting biofilm structure.
M proteins of group A Streptococcus bind hyaluronic acid via arginine-arginine/serine-arginine motifs.
FASEB J
October 2024
Molecular Horizons Research Institute and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.
Article Synopsis
- Tissue injury and ECM degradation are significant features of group A Streptococcus (GAS) skin infections, largely influenced by M proteins with lectin-like abilities.
- The study found that M proteins from different GAS strains bind to hyaluronic acid through specific motifs, which affects keratinocyte wound healing negatively.
- Understanding the interaction between hyaluronic acid and M proteins could help develop new nonantibiotic treatments to combat GAS skin infections by improving ECM composition and healing responses.
Estimated Population-Level Impact of Pneumococcal Conjugate Vaccines Against All-Cause Pneumonia Mortality Among Unvaccinated in 5 Latin American Countries.
J Infect Dis
October 2024
Comprehensive Immunization Program, Pan-American Health Organization, Washington, District of Columbia, USA.
Background: Pneumococcal conjugate vaccines (PCVs) provide strong direct protection in children, while limited data are available on their indirect effect on mortality among older age groups. This multicountry study aimed to assess the population-level impact of pediatric PCVs on all-cause pneumonia mortality among children ≥5 years of age, and invasive pneumococcal disease (IPD) cases in Chile.
Methods: Demographic and mortality data from Argentina, Brazil, Chile, Colombia, and Mexico were collected considering the ≥ 5-year-old population, from 2000 to 2019, with 1 795 789 deaths due to all-cause pneumonia.
Machine learning enabled multiplex detection of periodontal pathogens by surface-enhanced Raman spectroscopy.
Int J Biol Macromol
February 2024
Department of Chemistry, Illinois Institute of Technology, Chicago, IL 60616, United States of America. Electronic address:
Periodontitis is a chronic inflammation of the periodontium caused by a persistent bacterial infection, resulting in destruction of the supporting structures of teeth. Analysis of microbial composition in saliva can inform periodontal status. Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Streptococcus mutans (Sm) are among reported periodontal pathogens, and were used as model systems in this study.
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