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Effects of pethoxamid treatment on the disposition of thyroxine in rats.
Toxicol Appl Pharmacol
June 2024
FMC Corporation, 2929 Walnut St, Philadelphia, PA, USA. Electronic address:
Article Synopsis
- - Pethoxamid (PXA) is a chloroacetamide herbicide that inhibits weed germination and has been found to cause thyroid follicular cell hyperplasia in high-dose male rats, but does not act as a genotoxic agent.
- - A study assessed the effects of PXA on the disposition of intravenously administered radioactive thyroxine in bile-duct cannulated rats, compared with a positive control (phenobarbital), showing increased liver weights and altered thyroid hormone clearance.
- - The findings suggest PXA affects thyroid hormone balance through increased T4 elimination in bile due to enzyme induction mechanisms, but these effects are likely not relevant to humans due to species-specific differences in thyroid hormone metabolism.
The New Nematicide Cyclobutrifluram Targets the Mitochondrial Succinate Dehydrogenase Complex in .
J Dev Biol
October 2023
Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.
Today, agriculture around the world is challenged by parasitic nematode infections. Plant-parasitic nematodes (PPNs) can cause significant damage and crop loss and are a threat to food security. For a long time, the management of PPN infection has relied on nematicides that impact not only parasitic nematodes but also other organisms.
View Article and Find Full Text PDFMechanism of dasabuvir inhibition of acetaminophen glucuronidation.
J Pharm Pharmacol
January 2022
Program in Pharmacology and Drug Development, Tufts University Graduate School of Biomedical Science and School of Medicine, Boston, MA, USA.
Objectives: Acetaminophen (APAP) (paracetamol) is a widely used non-prescription drug for pain relief and antipyretic effects. The clearance of APAP is mainly through phase-2 biotransformation catalysed by UDP-glucuronosyl transferases (UGT). Dasabuvir is an anti-hepatitis C drug reported to inhibit several UGT isoforms.
View Article and Find Full Text PDFInhibitory effects of quercetin and its major metabolite quercetin-3-O-β-D-glucoside on human UDP-glucuronosyltransferase 1A isoforms by liquid chromatography-tandem mass spectrometry.
Exp Ther Med
August 2021
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Quercetin is a flavonoid that is widely present in plant-derived food. Quercetin-3-O-β-D-glucoside (Q3GA) is a predominant metabolite of quercetin in animal and human plasma. The inhibitory effects of the UDP-glucuronosyl transferases (UGTs) caused by herbal components may be a key factor for the clinical assessment of herb-drug interactions (HDIs).
View Article and Find Full Text PDFDose- and time-effects responses of Nonylphenol on oxidative stress in rat through the Keap1-Nrf2 signaling pathway.
Ecotoxicol Environ Saf
April 2021
The Key Laboratory of Food Quality and Safety of Guangdong Province, College of Food Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Nonylphenol (NP) is a representative environmental endocrine-disrupting compound that can induce oxidative stress in organisms. The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway acts an important role in preventing oxidative stress. The aim of this study was to investigate the influence of oxidative stress caused by NP on Keap1-Nrf2 pathway in rats.
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