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Occupational exposures and coronary heart disease in the Hamburg City Health Study (HCHS) - a cross-sectional study.
BMC Public Health
January 2025
Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Background: Coronary heart disease (CHD) is the leading cause of death among adults in Germany. There is evidence that occupational exposure to particulate matter, noise, psychosocial stressors, shift work and high physical workload are associated with CHD. The aim of this study is to identify occupations that are associated with CHD and to elaborate on occupational exposures associated with CHD by using the job exposure matrix (JEM) BAuA-JEM ETB 2018 in a German study population.
View Article and Find Full Text PDFVehicle-induced air pollutant dispersion and personal exposure in an urban street canyon: Association with air-source heat pump outdoor units combined with building envelope components.
Sci Total Environ
January 2025
School of Architecture, Southeast University, 2 Sipailou, Nanjing 210096, China.
Air-source heat pumps are popular in buildings to provide cooling and heating. However, how the air discharged by air-source heat pump outdoor units affects the dispersion of air pollutants in urban street canyons remains poorly understood. This study used coupled simulations to examine the effects that air-source heat pump outdoor units had on vehicle-induced indoor and outdoor air pollution in an urban street canyon and how these effects varied based on the arrangement of outdoor units or the presence of building envelope components (e.
View Article and Find Full Text PDFStability evaluation of tunnels in steeply dipping layered rock mass using numerical models: a case study.
Sci Rep
January 2025
Geotechnical and Mining Engineering Division, University of Western Macedonia, Kozani, Greece.
Tunnel stability is a critical factor in complex geological conditions, particularly in rock masses with steeply dipping layers. Among widely used methods, the Convergence-Confinement Method (CCM), a prevalent two-dimensional (2D) approach, effectively captures the relaxation process preceding support installation. However, most studies focus on homogeneous or horizontally layered rock masses, often overlooking the influence of steeply dipping, and layered geological formations.
View Article and Find Full Text PDFAssessment of concentrated solar power (CSP) generation potential in Cameroon using a Multi-Criteria Analysis Method and Geographic Information System (GIS).
Heliyon
January 2025
Environmental Energy Technologies Laboratory (EETL), Department of Physics, University of Yaounde I, P.O Box 812, Yaounde, Cameroon.
This research aims to identify wet-cooled CSP (Concentrated Solar Power) solar power plants connected to the existing electricity grid in Cameroon. This study uses a hybrid approach which combines an MDCM-AHP method (Multi-Criteria Analysis Method - Hierarchical Analysis Process) and a GIS (Geographic Information System). The elements studied are the climate (Direct Normal Irradiance (DNI), temperature), orography (slope and elevation) and location (proximity to the electricity network, proximity to roads and railways, proximity to homes), in order to determine the weight of these different factors and combine them to obtain the final map.
View Article and Find Full Text PDFIn vivo base editing extends lifespan of a humanized mouse model of prion disease.
Nat Med
January 2025
Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting PrP in the brain is an established strategy to prevent or stall templated misfolding of PrP. Here we developed in vivo cytosine and adenine base strategies delivered by adeno-associated viruses to permanently modify the PRNP locus to achieve PrP knockdown in the mouse brain.
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