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New horizons in the treatment of psoriasis: Modulation of gut microbiome.
Heliyon
January 2025
Department of Medical Microbiology, Tehran University of Medical Sciences, Tehran, Iran.
The last decennia have witnessed spectacular advances in our knowledge about the influence of the gut microbiome on the development of a wide swathe of diseases that extend beyond the digestive tract, including skin diseases like psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. The novel concept of the gut-skin axis delves into how skin diseases and the microbiome interact through inflammatory mediators, metabolites, and the intestinal barrier. Elucidating the effects of the gut microbiome on skin health could provide new opportunities for developing innovative treatments for dermatological diseases.
View Article and Find Full Text PDFGut bacterial sphingolipid production modulates dysregulated skin lipid homeostasis.
bioRxiv
December 2024
Divison of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Sphingolipids are an essential lipid component of the skin barrier with alterations in skin sphingolipid composition associated with multiple skin disorders including psoriasis, atopic dermatitis, and ichthyosis. Contributions to skin sphingolipid abundance are not well characterized, thus the main method of modulating skin lipid levels is the topical application of creams rich with sphingolipids at the skin surface. Evidence that diet and gut microbiome function can alter skin biology proposes an intriguing potential for the modulation of skin lipid homeostasis through gut microbial metabolism, but potential mechanisms of action are not well understood.
View Article and Find Full Text PDFMild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier.
Biochim Biophys Acta Mol Basis Dis
December 2024
Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden; Gastroenterology Research Group, Department of Medical Sciences, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Electronic address:
Psoriasis is a chronic skin disease occasionally associated with abdominal symptoms and IBD. We aimed to characterize intestinal immune cells and the integrity of the intestinal barrier in psoriasis. Biopsies from the duodenum and colon were analyzed by flow cytometry and immunohistochemistry for the presence and activation status of different immune cell populations.
View Article and Find Full Text PDFGut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin.
Microbiol Spectr
January 2025
Institute of Translational Biomedicine, Saint-Petersburg State University, Saint-Petersburg, Russia.
Unlabelled: Many studies have reported gut microbiome alterations in psoriasis patients, suggesting dysbiosis. While evidence for dysbiosis and its link to pathogenesis remains inconclusive, murine models of psoriasis suggest that gut microbiome alterations develop in response to psoriasis-like inflammation. Hence, the dominant narrative about gut microbiome alterations' impact on disease should be evaluated critically with more data and a well-powered approach.
View Article and Find Full Text PDFThe Role of Vitamin D3 Deficiency and Colonization of the Oral Mucosa by Yeast-like Fungi in the Pathomechanism of Psoriasis.
J Clin Med
November 2024
Department of Aesthetic Dermatology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Psoriasis is a chronic inflammatory skin disease with complex pathogenesis and variable severity. Performed studies have indicated the impact of vitamin D3 deficiency on the pathogenesis of psoriasis and its severity. However, there is no clear evidence of the influence of the mucosal microbiome on the onset and progression of psoriasis.
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