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Z-score evaluation and inferences for management of aortopathy patients.
Cardiol Young
January 2025
Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
Echocardiographic Z-score models play a crucial role in defining cardiac pathology in paediatric patients. There are multiple models that practitioners utilize in the United States without guiding principles to standardize their use. Discrepant interpretations can occur depending on the model chosen, even if standardized Z-score cutoffs are applied.
View Article and Find Full Text PDFThe mitochondriotropic antioxidants AntiOxBEN and AntiOxCIN are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts.
Biochim Biophys Acta Bioenerg
January 2025
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Mitochondrial dysfunction and increased reactive oxygen species (ROS) generation play an import role in different human pathologies. In this context, mitochondrial targeting of potentially protective antioxidants by their coupling to the lipophilic triphenylphosphonium cation (TPP) is widely applied. Employing a six‑carbon (C) linker, we recently demonstrated that mitochondria-targeted phenolic antioxidants derived from gallic acid (AntiOxBEN) and caffeic acid (AntiOxCIN) counterbalance oxidative stress in primary human skin fibroblasts by activating ROS-protective mechanisms.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.
Background: With a global ageing population, there is an increasing demand for fast and reliable early diagnosis of individuals. Convolutional neural networks (CNNs) have an immense potential in assisting clinicians in diagnosing dementia. Regional atrophy patterns, which are visible in T1-weighted MRI scans, have been consistently identified by the CNNs with high accuracy.
View Article and Find Full Text PDFBackground: Traumatic encephalopathy syndrome (TES) is a proposed framework for the clinical syndrome resulting from chronic traumatic encephalopathy and other neurodegenerative effects of repetitive head impacts (RHI). TES symptoms can mirror Alzheimer's disease (AD) despite absence of hallmark AD pathology. We investigated whether GFAP, NfL, and IL-6 correlated with cognition and brain volume changes within TES relative to AD.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Universidad Cesar Vallejo, Los Olivos, Lima, Peru.
Background: Background. According to the World Health Organization, dementia is one of the leading causes of disability in the elderly, imposing a significant burden on global public health. It is estimated that dementia affects over 55 million people worldwide, with 60% of them living in low- and middle-income countries.
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