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Hyaluronic acid-based hydrogels as codelivery systems: The effect of intermolecular interactions investigated by HR-MAS and solid-state NMR Spectroscopy.
Carbohydr Polym
February 2025
Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy. Electronic address:
Article Synopsis
- - Hydrogels made from hyaluronic acid and agarose-carbomer are being studied for their potential to simultaneously deliver multiple drugs for different diseases, thanks to their biocompatibility and unique 3D structure.
- - The study focuses on how ethosuximide and sodium salicylate interact and diffuse within these hydrogels, using advanced techniques like NMR Spectroscopy to analyze their transport properties.
- - Findings suggest that when both drugs are loaded together, they behave similarly in their diffusion patterns, which may be influenced by drug-drug interactions, leading to a proposed trapping-release mechanism that affects how the drugs are released from the hydrogels.
Protective Efficacy of T-type, Calcium Channel Antagonist on Auditory Function in Cdh23 Erl/Erl Mice.
Altern Ther Health Med
October 2024
Article Synopsis
- Calcium ions play a crucial role in hair cell functions and T-type calcium antagonists may help protect against hearing loss, yet there has been no research using T-type antagonists like ethosuximide in Cdh23 mouse models.
- The study aimed to assess the effectiveness of ethosuximide in preventing age-related hearing loss in Cdh23 erl/erl mice, potentially leading to therapeutic options for humans suffering from similar conditions.
- Researchers conducted an experiment with male and female Cdh23 mice, dividing them into a saline control group and an ethosuximide treatment group, measuring hearing responses and cell loss to evaluate the protective effects of the drug.
Lacosamide as an Adjunctive Therapy in Drug-Resistant Absence Epilepsy: Successful Treatment of Four Patients.
Iran J Child Neurol
September 2024
Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Absence epilepsy is one of the most common epileptic syndromes in children, and despite its benign nature, a percentage of these children are drug-resistant. This study presents four cases of drug-resistant absence epilepsy in children who were unresponsive to traditional antiepileptic drugs. The study reports the successful use of Lacosamide as an adjunctive therapy to completely control symptoms and electroencephalogram (EEG) abnormalities.
View Article and Find Full Text PDFEthosuximide-loaded bismuth ferrite nanoparticles as a potential drug delivery system for the treatment of epilepsy disease.
PLoS One
September 2024
Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, United States of America.
Encapsulating antiepileptic drugs (AEDs), including ethosuximide (Etho), into nanoparticles shows promise in treating epilepsy. Nanomedicine may be the most significant contributor to addressing this issue. It presents several advantages compared to traditional drug delivery methods and is currently a prominent area of focus in cancer research.
View Article and Find Full Text PDFCurcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites.
BMC Cancer
September 2024
Jiangxi Provincial Key Laboratory of Prevention and Treatment of Infectious Diseases, Jiangxi Medical Center for Critical Public Health Events, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330052, Jiangxi, P.R. China.
Article Synopsis
- - Curcumin shows potential for preventing and treating colorectal cancer (CRC) by influencing gut microbiota and its metabolites, although its exact mechanisms are not fully understood.
- - In a study with C57BL/6JGpt mice, curcumin treatment improved colon structure, reduced tumor formation, and positively altered gut bacteria diversity compared to CRC mice that did not receive curcumin.
- - The research found that curcumin decreased harmful bacteria and increased beneficial ones, along with identifying 13 metabolites that were altered in the CRC model group, suggesting a significant impact on gut health related to CRC.
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