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Sleeve gastrectomy improves HDL function examined by Apo-A1 and atherogenic indices in non-diabetic obese patients.
Cir Cir
January 2025
Department of General Surgery, Antalya Training and Research Hospital, Antalya, Turkey.
Objective: Dysregulation of lipid metabolism can be one of the pathophysiological mechanisms linking high-density lipoprotein cholesterol (HDL-C) dysfunction to obesity. The aim of the study is to show possible changes in lipid metabolism with atherogenic indices in obese patients after sleeve gastrectomy (SG) surgery.
Method: Thirty patients who had SG surgery for obesity were included in the prospective study.
Factors affecting the direct red cell effect on thrombosis: Hematocrit dilution and injury patterns.
J Trauma Acute Care Surg
December 2024
From the Department of Surgery, University of Cincinnati, Cincinnati, Ohio.
Background: Red blood cell (RBC) aggregation can be initiated by calcium and tissue factor, which may independently contribute to microvascular and macrovascular thrombosis after injury and transfusion. Previous studies have demonstrated that increased blood storage duration may contribute to thrombotic events. The aims of this study were to first determine the effect of blood product components, age, and hematocrit (HCT) on the aggregability of RBCs, followed by measurement of RBC aggregability in two specific injury models including traumatic brain injury (TBI) and hemorrhagic shock.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of São Paulo Universidade de São Paulo, São Paulo, Brazil.
Background: The Down Syndrome (DS), also referred to as trisomy of chromosome 21, is a prevalent cause of intellectual disability and also contributes to the acceleration of aging, among other developmental and health concerns. Certain pathological characteristics shared by DS and Alzheimer's Disease (AD) indicate similar commonalities. This study aims to unravel the relationship between the canonical Wnt/pathway, the amyloid precursor protein processing, the telomere shortening in DS individuals.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
Background: Plasma biomarkers show a promising future to improving the quality of diagnosing Alzheimer's Disease (AD). However, blood processing procedures should be considered when measuring plasma biomarkers. Here we investigate brain-derived neurotrophic factor (BDNF) in platelet-rich and platelet-poor plasma.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
University of California, San Francisco, San Francisco, CA, USA.
Background: Mitochondrial DNA copy number (mtDNAcn) quantifies the number of mitochondria genomes per nucleated cell, with reduced mtDNAcn being associated with increased Alzheimer's disease (AD) neuropathology. Blood-based mtDNAcn has technical confounders, such as DNA purification, and biological confounders, such as compensatory upregulation of mtDNA. Therefore, we optimized a protocol for mtDNAcn quantification using droplet digital PCR (ddPCR) by testing (i) whole peripheral blood mononuclear cells (PBMCs) vs platelet-depleted PBMCs, (ii) column-based DNA extraction vs cell lysate, and (iii) mitochondrial DNA replication (mtDNArep).
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