Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
1-Methylxanthine enhances memory and neurotransmitter levels.
PLoS One
January 2025
Radiant Research Services Pvt. Ltd., Bangalore, India.
1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine and might contribute to their activity. 1-MX is an adenosine receptor antagonist and increases the release and survivability of neurotransmitters; however, no study has addressed the potential physiological effects of 1-MX ingestion. The aim of this study was to compare the effect of 1-MX on memory and related biomarkers in rats compared to control.
View Article and Find Full Text PDFTracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia.
Nat Commun
January 2025
Institute of Anatomy and Cell Biology, Saarland University, Homburg, Germany.
Tracheal tuft cells shape immune responses in the airways. While some of these effects have been attributed to differential release of either acetylcholine, leukotriene C4 and/or interleukin-25 depending on the activating stimuli, tuft cell-dependent mechanisms underlying the recruitment and activation of immune cells are incompletely understood. Here we show that Pseudomonas aeruginosa infection activates mouse tuft cells, which release ATP via pannexin 1 channels.
View Article and Find Full Text PDFDifferential participation of CaMKII/ROCK and NOS pathways in the cholinergic inhibitory drive operated by nicotinic α7 receptors in perisynaptic Schwann cells.
Biochem Pharmacol
January 2025
Laboratório de Farmacologia e Neurobiologia, Instituto de Ciências Biomédicas de Abel Salazar Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal; Centro de Investigação Farmacológica e Inovação Medicamentosa (MedInUP/RISE-Health), Instituto de Ciências Biomédicas de Abel Salazar Universidade do Porto (ICBAS-UP), 4050-313 Porto, Portugal. Electronic address:
Nicotinic α7 receptors (α7 nAChRs) present in perisynaptic Schwann cells (PSCs) control acetylcholine (ACh) spillover from the neuromuscular synapse by transiently increasing intracellular Ca, which fosters adenosine release via type 1 equilibrative nucleoside transporters (ENT1) and retrograde activation of presynaptic A inhibitory receptors. The putative Ca-dependent pathways downstream α7 nAChRs involved in the sensing inhibitory drive operated by PSCs is unknown. Herein, we used phrenic nerve-hemidiaphragm preparations from Wistar rats.
View Article and Find Full Text PDFPrevalence of Coronary Microvascular Dysfunction and Epicardial Spasm in Patients With Angina and Myocardial Bridge.
J Soc Cardiovasc Angiogr Interv
September 2024
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington.
Article Synopsis
- Myocardial bridges (MB) are common vascular abnormalities but only a fraction relate to chest pain (angina); this study aimed to investigate coexisting conditions that might cause symptoms in patients with MB.
- Conducted at the University of Chicago, the study included 30 patients with MB experiencing chest pain, testing for various types of coronary spasm and coronary microvascular dysfunction using specific medical tests.
- Findings revealed that 60% had endothelium-independent coronary microvascular dysfunction, 29% had microvascular spasm, and 37% had epicardial spasm, with most patients showing at least one of these abnormalities regardless of whether the MB was deemed hemodynamically significant.
Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes.
Nat Commun
November 2024
Centre for Cellular and Molecular Neurobiology, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Article Synopsis
- Astrocytes play crucial and underestimated roles in modulating neuronal circuits, particularly in the striatum, where they regulate dopamine transmission and interact closely with cholinergic interneurons (ChIs).
- The study reveals that striatal astrocytes rapidly excite ChIs and influence dopamine release through nicotinic acetylcholine receptors, operating on very fast timescales.
- A unique anatomical configuration is observed, where ChI somata are closely located to astrocyte somata, allowing for a dynamic interaction that regulates ChI excitability and extracellular calcium, thus impacting overall striatal circuit activity and dopamine signaling.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!