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A Case of Severe Erythroderma in a Patient with Pustular Psoriasis.
Clin Pract Cases Emerg Med
November 2024
University of Utah, Department of Emergency Medicine, Salt Lake City, Utah.
Case Presentation: A female patient with a known history of pustular psoriasis presented with sub-acute development of diffuse erythema and scaling of the skin with areas of exfoliation consistent with erythroderma. She was ill appearing and required admission and aggressive treatment with steroid-impregnated wet dressings, topical emollients, analgesics, and systemic immunosuppressants.
Discussion: Erythroderma is a dermatologic emergency characterized by diffuse erythema and scaling spanning greater than 90% of skin surfaces and is associated with a mortality rate as high as 64%.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Erythroderma Following Pfizer-BioNTech COVID-19 Vaccination in a Patient With Atopic Dermatitis: A Case Report.
Cureus
September 2024
Dermatology, Imperial Dermatology, Hollywood, USA.
Article Synopsis
- Cutaneous reactions to mRNA COVID-19 vaccines can include various skin issues, especially in patients with existing dermatologic diseases.
- A case report details a 73-year-old man with atopic dermatitis who developed severe erythroderma after each Pfizer-BioNTech vaccine dose, which covered 95% of his body.
- Quick identification and treatment of erythroderma are crucial to prevent serious complications, highlighting the need for awareness of this reaction in susceptible individuals.
A case of revertant mosaic-like normal-looking spots in a patient with erythroderma with IL36RN and CARD14 heterozygous mutations.
J Dermatol
December 2024
Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
Article Synopsis
- An 89-year-old woman from Japan had a skin condition that made her skin very red and scaly.
- Doctors found some unusual changes in her skin cells and discovered she had mutations in two specific genes (IL36RN and CARD14).
- She later developed small, round spots on her skin that looked normal, but tests showed these spots might be different from her red, scaly skin despite having the same gene mutations.
Resolution of Molluscum Contagiosum After Discontinuation of Topical Corticosteroids During Dupilumab Therapy for Atopic Dermatitis: A Case Report.
Cureus
August 2024
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, JPN.
A 35-year-old male patient with atopic dermatitis (AD) was referred to our department for exacerbated AD lesions. His sudden discontinuation of topical corticosteroid had induced erythroderma on his face, extremities, and trunk. Additionally, he presented small multiple whitish papules, mainly on the trunk and thighs, diagnosed as molluscum contagiosum (MC).
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