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Detection of Francisellaceae and the differentiation of main European F. tularensis ssp. holarctica strains (Clades) by new designed qPCR assays.

BMC Microbiol

January 2025

Cellular Interactions of Bacterial Pathogens, Centre for Biological Threats and Special Pathogens, Highly Pathogenic Microorganisms (ZBS 2), Robert Koch Institute, Seestraße 10, 13353, Berlin, Germany.

Background: The zoonotic and highly infectious pathogen Francisella tularensis is the etiological agent of tularemia. Tularemia in humans is mainly caused by F. tularensis subspecies tularensis and holarctica, but Francisella species like F.

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Article Synopsis
  • Tularemia, caused by the bacterium Francisella tularensis, poses a significant threat to human health but lacks extensive data on its distribution in blood-feeding arthropods.
  • A study conducted in the Břeclav district in 2022 screened various hematophagous vectors, including ticks, mosquitoes, and blackflies, to check for the presence of this bacterium.
  • The results revealed only two positive samples for F. tularensis subsp. holarctica, both from the tick species Dermacentor reticulatus, while no presence was found in mosquitoes or blackflies.
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The great tularemia outbreak in Sivas: Evaluation of 205 cases.

Diagn Microbiol Infect Dis

January 2025

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey.

This study aimed to report a tularemia outbreak in Sivas and describe the epidemiological and diagnostic characteristics of the patients. Patients aged 18 and over followed up with a diagnosis of tularemia in Sivas Cumhuriyet University Hospital, Sivas Numune State Hospital, and Sivas State Hospital Infectious Diseases Outpatient Clinics and wards between November 2023 and May 2024 were evaluated. 205 adult patients with tularemia were included.

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Article Synopsis
  • - The study aimed to analyze clinical features in cats diagnosed with tularemia, comparing those with and without the disease and identifying factors that increase the chance of a tularemia diagnosis.
  • - Through the analysis of medical records from 2000 to 2021, the research found that affected cats were mostly middle-aged male domestic shorthairs with outdoor access, often presenting symptoms like lethargy, anorexia, and fever, among other findings.
  • - Key results indicated that leukopenia and neutropenia were significantly more common in cats with positive PCR tests for tularemia, suggesting that these blood abnormalities can be important indicators of the disease.
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Article Synopsis
  • - A retrospective analysis in Canada from 2009 to 2021 studied hospitalization rates for tick-borne diseases (TBDs), focusing on demographics, trends, and geographic distribution using health data from the Discharge Abstract Database (DAD).
  • - Out of 1,626 hospitalizations for TBDs, the majority were Lyme disease (1,457 cases), with significant annual increases noted, particularly rising from 50 cases in 2009 to 259 in 2021.
  • - Other TBDs diagnosed included rickettsiosis, tularemia, and babesiosis, with rickettsiosis showing the only increase in cases; overall, this study highlights the growing burden of TBDs and identifies populations at risk.
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