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KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary.
Kidney Int
February 2025
Institute of Physiology, University of Zurich, Zurich, Switzerland; Division of Nephrology, Cliniques universitaires Saint-Luc, UCLouvain Medical School, Brussels, Belgium. Electronic address:
The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) represents the first KDIGO guideline on this subject. Its scope includes nomenclature, diagnosis, prognosis, and prevalence; kidney manifestations; chronic kidney disease (CKD) management and progression, kidney failure, and kidney replacement therapy; therapies to delay progression of kidney disease; polycystic liver disease; intracranial aneurysms and other extrarenal manifestations; lifestyle and psychosocial aspects; pregnancy and reproductive issues; pediatric issues; and approaches to the management of people with ADPKD. The guideline has been developed with patient partners, clinicians, and researchers around the world, with the goal to generate a useful resource for healthcare providers and patients by providing actionable recommendations.
View Article and Find Full Text PDFMaternal and neonatal outcomes in pregnant women undergoing cardiac surgery: a systematic review and meta-analysis.
J Matern Fetal Neonatal Med
December 2025
Department of Gynaecology, Huzhou Maternity and Child Health Care Hospital, Huzhou City, Zhejiang Province, China.
Objective: Cardiac diseases that require surgical intervention present a unique challenge during pregnancy and may affect both maternal and neonatal outcomes. This systematic review and meta-analysis aimed to evaluate maternal and neonatal outcomes in pregnant females undergoing cardiac surgery.
Methods: A comprehensive manual and electronic search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Sciences databases for studies published up to 31 May 2024.
Associations of Pregnancy Timing Relative to the COVID-19 Pandemic, Maternal SARS-CoV-2 Infection, and Adverse Perinatal Outcomes.
Ann Epidemiol
January 2025
South Carolina SmartState Center for Healthcare Quality, South Carolina, USA; Department of Health Promotion, Education and Behavior, University of South Carolina Arnold School of Public Health, Institution address: 915 Greene Street, Columbia, SC 29208, USA. Electronic address:
Purpose: To examine associations between COVID-19 pandemic and maternal SARS-CoV-2 infection with perinatal outcomes.
Methods: We conducted a retrospective cohort study of 189,097 singleton births in South Carolina (2018-2021). Pregnancy timing relative to the pandemic was classified as pre-pandemic (delivered before March 1, 2020), partial pandemic overlap (conceived before and delivered during the pandemic), or pandemic (conceived and delivered during the pandemic).
Association between adverse perinatal events and postpartum depressive symptoms in a North American prospective preconception cohort study.
J Affect Disord
January 2025
Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, Boston, MA, USA.
Background: Identifying risk factors for postpartum depression (PPD) is critical to inform early intervention efforts. This study investigated the impact of adverse perinatal events on PPD.
Methods: We analyzed data from the Pregnancy Study Online (PRESTO), a North American prospective preconception cohort study.
Placental mesenchymal dysplasia in a monochorionic-diamniotic twin pregnancy complicated with hydrops fetalis-with a review of literature.
Eur J Obstet Gynecol Reprod Biol
January 2025
Department of Obstetrics and Gynecology, Ministry of Health, Ankara Bilkent City Hospital, Ankara, Turkey; University of Health Sciences, Ankara Bilkent City Hospital, Ankara, Turkey.
Placental mesenchymal dysplasia (PMD) is a rare placental pathology that sonographically mimics gestational trophoblastic diseases. However, mesenchymal dysplasia can be distinguished from other conditions by the presence of villous edema and the absence of trophoblastic proliferation in the placental tissue. This pathology has been demonstrated to be associated with fetal growth restriction, Beckwith-Wiedemann syndrome, some chromosomal abnormalities and intrauterine fetal demise.
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