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Anaesthetic management of liver transplantation in patients with fulminant hepatic failure.
J Pak Med Assoc
January 2025
Department of Anaesthesia, Shifa International Hospital, Islamabad, Pakistan.
Acute Liver Failure (ALF) is associated with rapidly progressive multiorgan failure and may even lead to death. Although liver transplantation (LT) has emerged as the only viable treatment option, there are many challenges associated with LT. The literature available from developed countries mainly focuses on the prognosis of ALF with limited focus on the anaesthetic management of LT.
View Article and Find Full Text PDFViscoelastic haemostatic assays to guide therapy in elective surgery: an updated systematic review and meta-analysis.
Anaesthesia
January 2025
Haemonetics Corp, Boston, MA, USA.
Article Synopsis
Impact of introduction of a goal directed transfusion strategy in a patient blood management program: A single cardiac surgery centre experience.
Transfus Med
August 2024
S.C. Immunoematologia e Centro Trasfusionale, ASST Ovest Milanese, Legnano, Italy.
Background: The aim of this retrospective and observational study was to analyse the impact of the introduction of a goal directed transfusion (GDT) strategy based on a viscoelastic test (ROTEM®) and specific procoagulant products in a patient blood management (PBM) Program on blood product use and perioperative bleeding in a single cardiac surgery centre.
Study Design And Methods: Patient population underwent cardiac surgery from 2011 to 2021 was divided in two groups based on PBM protocol used (G#11-14, years 2011-2014, G#15-21, years 2015-2021) and compared for the following variables: intraoperative and postoperative transfusions of packed red blood cell and any procoagulant products, postoperative drain blood loss volume and rate of re-exploration surgery. The second program was defined after the introduction of a GDT protocol based on viscoelastic tests and specific procoagulant products.
Factor XIII in major burns coagulation.
Burns
September 2024
Anesthesia and Critical Care Department, University Bellvitge Hospital, University of Barcelona, Barcelona, Spain. Electronic address:
Background: In the days following a burn injury, major burn patients (MBP) present a multifactorial coagulation disorder known as acute burn-induced coagulopathy. Several studies have investigated coagulation in MBPs; however, Factor XIII (FXIII), which converts fibrin monomers into a stable clot and promotes wound healing, has not yet been studied.
Objective: To determine the kinetics of FXIII and other coagulation factors and cofactors in MBPs in order to clarify coagulopathy in these patients and its potential relationship with surgical bleeding.
Thromboelastometry-Based Prophylaxis for Venous Thromboembolism in the Acute Period Following Isolated Severe Traumatic Brain Injury.
Korean J Neurotrauma
March 2024
Laboratory of Biomedical Informatics and Artificial Intelligence, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation, Moscow, Russian Federation.
Objective: Traumatic brain injury (TBI) is an independent risk factor for venous thromboembolism (VTE). This study aimed to determine the optimal timing for initiating pharmacological thromboprophylaxis for VTE in patients with isolated severe TBI using rotational thromboelastometry (ROTEM).
Methods: This single-center observational study enrolled 115 patients aged 18-59 years with isolated severe TBI within the first 48 hours after injury.
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