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Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder.
Clin Psychopharmacol Neurosci
November 2024
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Objective: Bipolar disorder (BD) is marked by significant change in mood and energy levels with sleep disturbance a common feature, resulting in diminished quality of life and impaired daily functioning. This study assessed the association between BD-polygenic risk scores (PRS) and hypnotics in bipolar I disorder (BD-I) patients.
Methods: Large-sample data were collected from the genome-wide association study of a multicenter Bipolar Genomic Study, and 1,394 BD-I patients with available medication information were divided into two groups depending on whether they used hypnotics or not.
Integrating network pharmacology and experimental evaluation to explore the complementary therapeutic effect and mechanism of melatonin in periodontitis.
Heliyon
June 2024
College of Stomatology, Chongqing Medical University, Chongqing, 401147, China.
Objective: To explore the potential targets for melatonin in the treatment of periodontitis through network pharmacologic analysis and experimental validation via animal models and cellular experiments.
Materials And Methods: In this study, we first screened melatonin targets from Pharm Mapper for putative targets, Drug Bank, and TCMSP databases for known targets. Then, disease database was searched and screened for differential expressed genes associated with periodontitis.
Gut microbiota regulates host melatonin production through epithelial cell MyD88.
Gut Microbes
February 2024
State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou, China.
Article Synopsis
- Melatonin plays key roles in regulating circadian rhythms, inflammation, and gut health, but its interaction with gut microbiota is not fully understood.
- In studies with mice, it was found that those treated with antibiotics or raised in germ-free conditions had lower melatonin levels in their blood and higher levels in their colon.
- The research identified that gut microbes influence melatonin production via specific signaling pathways, suggesting potential new treatment approaches for conditions linked to melatonin.
Central precocious puberty secondary to peripheral precocious puberty due to a pineal germ cell tumor: a case and review of literature.
BMC Endocr Disord
October 2023
Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Background: The pineal lesion affecting melatonin is a rare cause of central precocious puberty by decreasing the inhibition of hypothalamic-pituitary-gonadal axis. Germ cell tumor secreting human chorionic gonadotropin is a rare cause of peripheral puberty.
Case Presentation: A 5.
Alterations of Gut-Derived Melatonin in Neurobehavioral Impairments Caused by Zinc Oxide Nanoparticles.
Int J Nanomedicine
April 2023
Research Center for Environment and Human Health, School of Public Health, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Purpose: The widespread use of zinc oxide nanoparticles (ZnONPs) has raised concerns about its potential toxicity. Melatonin is a neurohormone with tremendous anti-toxic effects. The enterochromaffin cells are an essential source of melatonin in vivo.
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